| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Endocrinology and Metabolism, Vol 272, Issue 6 E1050-E1058, Copyright © 1997 by American Physiological Society
ARTICLES |
P. L. Brubaker, A. Izzo, M. Hill and D. J. Drucker
Department of Physiology, University of Toronto, Ontario, Canada.
Glucagon-like peptide-2 (GLP-2) stimulates small intestinal growth through induction of intestinal epithelial proliferation. To examine the physiology of GLP-2-induced bowel, mice were treated with GLP-2 (2.5 micrograms) or vehicle for 10 days. Small intestinal weight increased to 136 +/- 2% of controls in GLP-2-treated mice, in parallel with 1.4 +/- 0.1- and 1.9 +/- 0.5-fold increments in duodenal RNA and protein content, respectively (P < 0.05-0.001). Similarly, the activities of duodenal maltase, sucrase, lactase, glutamyl transpeptidase, and dipeptidyl-peptidase IV (215 +/- 28% of controls; P < 0.001) were increased by GLP-2. Oral or duodenal administration of glucose or maltose did not reveal any differences in the ability of GLP-2-treated mice to absorb these nutrients, possibly because of decreases in expression of the glucose transporters sodium-dependent glucose transporter-1 (SGLT-1) and GLUT-2. In contrast, absorption of leucine plus triolein was increased after duodenal administration in GLP-2-treated mice (P < 0.01-0.001). Finally, GLP-2 did not alter other markers of intestinal or pancreatic gene expression, including levels of mRNA transcripts for ornithine decarboxylase, multidrug resistance gene, amylase, proglucagon, proinsulin, and prosomatostatin. Thus induction of intestinal growth by GLP-2 in wild-type mice results in a normal-to-increased capacity for nutrient digestion and absorption in vivo.
This article has been cited by other articles:
|
|
 |
|
  S. C. McDonagh, J. Lee, A. Izzo, and P. L. Brubaker Role of glial cell-line derived neurotropic factor family receptor {alpha}2 in the actions of the glucagon-like peptides on the murine intestine Am J Physiol Gastrointest Liver Physiol, August 1, 2007; 293(2): G461 - G468. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Anini, A. Izzo, G. Y. Oudit, P. H. Backx, and P. L. Brubaker Role of phosphatidylinositol-3 kinase-{gamma} in the actions of glucagon-like peptide-2 on the murine small intestine Am J Physiol Endocrinol Metab, June 1, 2007; 292(6): E1599 - E1606. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. L. BRUBAKER The Glucagon-Like Peptides: Pleiotropic Regulators of Nutrient Homeostasis Ann. N.Y. Acad. Sci., July 1, 2006; 1070(1): 10 - 26. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Cottrell, B. Stoll, R. K. Buddington, J. E. Stephens, L. Cui, X. Chang, and D. G. Burrin Glucagon-like peptide-2 protects against TPN-induced intestinal hexose malabsorption in enterally refed piglets Am J Physiol Gastrointest Liver Physiol, February 1, 2006; 290(2): G293 - G300. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M Sinclair and D. J. Drucker Proglucagon-Derived Peptides: Mechanisms of Action and Therapeutic Potential Physiology, October 1, 2005; 20(5): 357 - 365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Iordache, L. Drozdowski, M. T. Clandinin, G. Wild, Z. Todd, and A. B. R. Thomson Treatment of suckling rats with GLP-2 plus dexamethasone increases the ileal uptake of fatty acids in later life Am J Physiol Gastrointest Liver Physiol, January 1, 2005; 288(1): G54 - G59. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. R. Martin, L. E. Wallace, and D. L. Sigalet Glucagon-like peptide-2 induces intestinal adaptation in parenterally fed rats with short bowel syndrome Am J Physiol Gastrointest Liver Physiol, June 1, 2004; 286(6): G964 - G972. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ramsanahie, M. S. Duxbury, T. C. Grikscheit, A. Perez, D. B. Rhoads, J. Gardner-Thorpe, J. Ogilvie, S. W. Ashley, J. P. Vacanti, and E. E. Whang Effect of GLP-2 on mucosal morphology and SGLT1 expression in tissue-engineered neointestine Am J Physiol Gastrointest Liver Physiol, December 1, 2003; 285(6): G1345 - G1352. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Cameron, P.-C. Yang, and M. H. Perdue Glucagon-like peptide-2-enhanced barrier function reduces pathophysiology in a model of food allergy Am J Physiol Gastrointest Liver Physiol, June 1, 2003; 284(6): G905 - G912. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. E. Mayo, L. J. Miller, D. Bataille, S. Dalle, B. Goke, B. Thorens, and D. J. Drucker International Union of Pharmacology. XXXV. The Glucagon Receptor Family Pharmacol. Rev., March 1, 2003; 55(1): 167 - 194. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Anini and P. L. Brubaker Role of Leptin in the Regulation of Glucagon-Like Peptide-1 Secretion Diabetes, February 1, 2003; 52(2): 252 - 259. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D J Drucker Gut adaptation and the glucagon-like peptides Gut, March 1, 2002; 50(3): 428 - 435. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Burrin, Y. Petersen, B. Stoll, and P. Sangild Glucagon-Like Peptide 2: A Nutrient-Responsive Gut Growth Factor J. Nutr., March 1, 2001; 131(3): 709 - 712. [Abstract] [Full Text]
|
|
|
|
|
|
M A Benjamin, D M McKay, P-C Yang, H Cameron, and M H Perdue Glucagon-like peptide-2 enhances intestinal epithelial barrier function of both transcellular and paracellular pathways in the mouse Gut, July 1, 2000; 47(1): 112 - 119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Rao and A. S. Verkman Analysis of organ physiology in transgenic mice Am J Physiol Cell Physiol, July 1, 2000; 279(1): C1 - C18. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Xiao, R. P. Boushey, M. Cino, D. J. Drucker, and P. L. Brubaker Circulating levels of glucagon-like peptide-2 in human subjects with inflammatory bowel disease Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2000; 278(4): R1057 - R1063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Kitchen, A. J. Fitzgerald, R. A. Goodlad, N. F. Barley, M. A. Ghatei, S. Legon, S. R. Bloom, A. Price, J. R. F. Walters, and A. Forbes Glucagon-like peptide-2 increases sucrase-isomaltase but not caudal-related homeobox protein-2 gene expression Am J Physiol Gastrointest Liver Physiol, March 1, 2000; 278(3): G425 - G428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Tavares, D. J. Drucker, and P. L. Brubaker Enzymatic- and renal-dependent catabolism of the intestinotropic hormone glucagon-like peptide-2 in rats Am J Physiol Endocrinol Metab, January 1, 2000; 278(1): E134 - E139. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Munroe, A. K. Gupta, F. Kooshesh, T. B. Vyas, G. Rizkalla, H. Wang, L. Demchyshyn, Z.-J. Yang, R. K. Kamboj, H. Chen, et al. Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2 PNAS, February 16, 1999; 96(4): 1569 - 1573. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Drucker, B. Yusta, R. P. Boushey, L. DeForest, and P. L. Brubaker Human [Gly2]GLP-2 reduces the severity of colonic injury in a murine model of experimental colitis Am J Physiol Gastrointest Liver Physiol, January 1, 1999; 276(1): G79 - G91. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. B. Scott, D. Kirk, W. K. MacNaughton, and J. B. Meddings GLP-2 augments the adaptive response to massive intestinal resection in rat Am J Physiol Gastrointest Liver Physiol, November 1, 1998; 275(5): G911 - G921. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Drucker, L. Deforest, and P. L. Brubaker Intestinal response to growth factors administered alone or in combination with human [Gly2]glucagon-like peptide 2 Am J Physiol Gastrointest Liver Physiol, December 1, 1997; 273(6): G1252 - G1262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Mottino, T. Hoffman, P. A. Dawson, M. G. Luquita, J. A. Monti, E. J. Sanchez Pozzi, V. A. Catania, J. Cao, and M. Vore Increased expression of ileal apical sodium-dependent bile acid transporter in postpartum rats Am J Physiol Gastrointest Liver Physiol, January 1, 2002; 282(1): G41 - G50. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
