AJP - Endocrinology and Metabolism, Vol 272, Issue 4 E634-E640, Copyright © 1997 by American Physiological Society

ARTICLES

Insulin secretion in adult rats that had experienced different underfeeding patterns during their development

M. A. Martin, C. Alvarez, L. Goya, B. Portha and A. M. Pascual-Leone
Instituto de Bioquimica (Centro Mixto Consejo Superior de Investigaciones Cientificas-Universidad Complutense Madrid), Facultad de Farmacia, Spain.

Four populations of 70-day-old undernourished rats were studied. All rats were submitted to a 65% restriction of food intake as follows: 1) undernutrition of the mother from day 14 of gestation until birth only (fetal period, group F), 2) undernourished during fetal and suckling periods only (group FS), 3) undernourished from day 14 of gestation until day 70 of life (group FSA), and 4) undernourished from day 28 of life until day 70 (group A). Body weight, plasma glucose, glucose tolerance, basal plasma insulin, in vivo glucose-induced insulin secretion, pancreatic insulin content, and in vitro response of isolated islets to glucose and amino acids were investigated. Islet insulin content decreased in all four groups studied, and islet mass was found reduced in group FSA. Glucose tolerance was decreased in group A, and in vitro response of islets decreased in both groups FSA and A. We conclude that two different adaptive processes should be considered: the possible long-term consequences of impaired pancreas development due to inadequate perinatal nutrition and the functional alteration of insulin secretion to undernutrition in adulthood.

This article has been cited by other articles:

				E. Fernandez, M. A. Martin, S. Fajardo, F. Escriva, and C. Alvarez Increased IRS-2 content and activation of IGF-I pathway contribute to enhance beta-cell mass in fetuses from undernourished pregnant rats Am J Physiol Endocrinol Metab, January 1, 2007; 292(1): E187 - E195. [Abstract] [Full Text] [PDF]

				E. Fernandez, M. A. Martin, S. Fajardo, D. Bailbe, M. N. Gangnerau, B. Portha, F. Escriva, P. Serradas, and C. Alvarez Undernutrition does not alter the activation of beta-cell neogenesis and replication in adult rats after partial pancreatectomy Am J Physiol Endocrinol Metab, November 1, 2006; 291(5): E913 - E921. [Abstract] [Full Text] [PDF]

				M. A. Martin, E. Fernandez, A. M. Pascual-Leone, F. Escriva, and C. Alvarez Protein calorie restriction has opposite effects on glucose metabolism and insulin gene expression in fetal and adult rat endocrine pancreas Am J Physiol Endocrinol Metab, April 1, 2004; 286(4): E542 - E550. [Abstract] [Full Text] [PDF]

				L. Chen, T. Zhang, and B. L. G. Nyomba Insulin resistance of gluconeogenic pathways in neonatal rats after prenatal ethanol exposure Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2004; 286(3): R554 - R559. [Abstract] [Full Text] [PDF]

				M. Agote, L. Goya, S. Ramos, C. Alvarez, M. L. Gavete, A. M. Pascual-Leone, and F. Escriva Glucose uptake and glucose transporter proteins in skeletal muscle from undernourished rats Am J Physiol Endocrinol Metab, November 1, 2001; 281(5): E1101 - E1109. [Abstract] [Full Text] [PDF]

				D. E. Flanagan, V. M. Moore, I. F. Godsland, R. A. Cockington, J. S. Robinson, and D. I. W. Phillips Fetal growth and the physiological control of glucose tolerance in adults: a minimal model analysis Am J Physiol Endocrinol Metab, April 1, 2000; 278(4): E700 - E706. [Abstract] [Full Text] [PDF]

				E. Bertin, M.-N. Gangnerau, D. Bailbe, and B. Portha Glucose metabolism and beta -cell mass in adult offspring of rats protein and/or energy restricted during the last week of pregnancy Am J Physiol Endocrinol Metab, July 1, 1999; 277(1): E11 - E17. [Abstract] [Full Text] [PDF]

				M. D. McArthur, D. You, K. Klapstein, and D. T. Finegood Glucose effectiveness is the major determinant of intravenous glucose tolerance in the rat Am J Physiol Endocrinol Metab, April 1, 1999; 276(4): E739 - E746. [Abstract] [Full Text] [PDF]