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Am J Physiol Endocrinol Metab 272: E245-E247, 1997;
0193-1849/97 $5.00
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AJP - Endocrinology and Metabolism, Vol 272, Issue 2 E245-E247, Copyright © 1997 by American Physiological Society

ARTICLES

C-peptide does not alter carbohydrate metabolism in isolated mouse muscle

P. N. Shashkin, Y. Jiao, H. Westerblad and A. Katz
Division of Clinical Physiology, Department of Surgical Sciences, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden.

The effects of C-peptide on carbohydrate metabolism in isolated mouse soleus muscle were studied. C-peptide, at concentrations up to 1,000 nM, had no effect on [14C]glucose incorporation into glycogen, glycogen synthase activity, or 2-deoxyglucose uptake. These data demonstrate that C-peptide has no direct effect on the measured parameters of carbohydrate metabolism in isolated mouse muscle.




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