AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 272: E233-E238, 1997;
0193-1849/97 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jackman, M. L.
Right arrow Articles by Graham, T. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jackman, M. L.
Right arrow Articles by Graham, T. E.

AJP - Endocrinology and Metabolism, Vol 272, Issue 2 E233-E238, Copyright © 1997 by American Physiological Society

ARTICLES

Nutritional status affects branched-chain oxoacid dehydrogenase activity during exercise in humans

M. L. Jackman, M. J. Gibala, E. Hultman and T. E. Graham
Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada.

We examined the effect of glycogen availability and branched-chain amino acid (BCAA) supplementation on branched-chain oxoacid dehydrogenase (BCOAD) activity during exercise. Six subjects cycled at approximately 75% of their maximal oxygen uptake to exhaustion on three occasions under different preexercise conditions: 1) low muscle glycogen (LOW), 2) low muscle glycogen plus BCAA supplementation (LOW+BCAA), and 3) high muscle glycogen (CON). The LOW trial was performed first, followed by the other two conditions in random order, and biopsies for all trials were obtained at rest, after 15 min of exercise (15 min), and at the point of exhaustion during the LOW trial (49 min). BCOAD activity was not different among the three conditions at rest; however, at 15 min BCOAD activity was higher (P < or = 0.05) for the LOW (31 +/- 5%) and LOW+BCAA (43 +/- 11%) conditions compared with CON (12 +/- 1%). BCOAD activity at 49 min was not different from respective values at 15 min for any condition. These data indicate that BCOAD is rapidly activated during submaximal exercise under conditions associated with low carbohydrate availability. However, there was no relationship between BCOAD activity and glycogen concentration or net glycogenolysis, which suggests that factors other than glycogen availability are important for BCOAD regulation during exercise in humans.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. R. Howarth, K. A. Burgomaster, S. M. Phillips, and M. J. Gibala
Exercise training increases branched-chain oxoacid dehydrogenase kinase content in human skeletal muscle
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1335 - R1341.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. J. Gibala, M. Lozej, M. A. Tarnopolsky, C. McLean, and T. E. Graham
Low glycogen and branched-chain amino acid ingestion do not impair anaplerosis during exercise in humans
J Appl Physiol, November 1, 1999; 87(5): 1662 - 1667.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online