AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 271: E814-E820, 1996;
0193-1849/96 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stunff, C. L.
Right arrow Articles by Bougneres, P. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stunff, C. L.
Right arrow Articles by Bougneres, P. F.

AJP - Endocrinology and Metabolism, Vol 271, Issue 5 E814-E820, Copyright © 1996 by American Physiological Society

ARTICLES

Alterations of plasma lactate and glucose metabolism in obese children

C. L. Stunff and P. F. Bougneres
Institut National de la Sante et de la Recherche Medicale Unite 342, Rene Descartes University, Hopital Saint Vincent de Paul, Paris, France.

Using a double stable isotope infusion method, we quantified plasma glucose and lactate inter-relationships in five recently obese children. Compared with five age-matched controls, obese children had an approximately 50% increase of total body lactate turnover [167 +/- 20 vs. 111 +/- 20 (SE) mg/min, P < 0.05]. The rate of lactate conversion to glucose was double the normal rate (96 +/- 21 vs. 46 +/- 10 mg/min, P < 0.05). Increased gluconeogenesis from plasma lactate correlated with total glucose production (r = 0.74), with plasma lactate contributing to 58% of glucose production in obese children vs. 38% in normal children (P < 0.05). Conversion into glucose correlated with the rate of lactate release in the circulation (r = 0.76). In turn, the obese children converted a larger fraction (35 +/- 2 vs. 27 +/- 2%, P < 0.02) and amount (58 +/- 10 vs. 34 +/- 5 mg/min, P < 0.05) of glucose into plasma lactate. The amount of lactate originating from plasma glucose correlated (r = 0.70) with lipid oxidation, which was increased in the obese children (58 +/- 4 vs. 23 +/- 5 mg/min, P < 0.02). Our data suggest that increased gluconeogenesis from lactate is associated with increased lipid oxidation and could contribute to the progressive development of insulin resistance and glucose intolerance in juvenile obesity.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
S. R. Commerford, J. B. Ferniza, M. E. Bizeau, J. S. Thresher, W. T. Willis, and M. J. Pagliassotti
Diets enriched in sucrose or fat increase gluconeogenesis and G-6-Pase but not basal glucose production in rats
Am J Physiol Endocrinol Metab, September 1, 2002; 283(3): E545 - E555.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. A. Podolin, Y. Wei, and M. J. Pagliassotti
Effects of a high-fat diet and voluntary wheel running on gluconeogenesis and lipolysis in rats
J Appl Physiol, April 1, 1999; 86(4): 1374 - 1380.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online