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Am J Physiol Endocrinol Metab 271: E643-E648, 1996;
0193-1849/96 $5.00
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AJP - Endocrinology and Metabolism, Vol 271, Issue 4 E643-E648, Copyright © 1996 by American Physiological Society

ARTICLES

In vivo effects of dexamethasone and sucrose on glucose transport (GLUT-4) protein tissue distribution

L. Coderre, G. A. Vallega, P. F. Pilch and S. R. Chipkin
Department of Biochemistry, Boston University School of Medicine, Massachusetts 02118, USA.

Tissue-specific changes in GLUT-4 were compared in the following three different rat models by inducing varying degrees of hyperinsulinemia with or without hyperglycemia and hypertriglyceridemia: 1) sucrose feeding (Suc), 2) subcutaneous dexamethasone administration (Dex), and 3) a combination of both treatments (Dex/Suc). Suc raised circulatory insulin and triglyceride levels without affecting plasma glucose, whereas both Dex and Dex/Suc induced significant hyperinsulinemia, hyperglycemia, and hypertriglyceridemia. In adipocytes and skeletal muscle, Suc feeding was not associated with any change in total cellular GLUT-4 levels. However, Suc induced a sevenfold increase in fat cell plasma membrane GLUT-4 levels in the basal state and inhibited GLUT-4 translocation in response to insulin. Administration of Dex or Dex/Suc diminished GLUT-4 expression in fat cells, increased it in skeletal muscle, but did not induce any change in heart. Similar to Suc feeding, Dex and Dex/Suc also increased the amount of GLUT-4 detected at the plasma membrane of adipocytes in the basal state and inhibited GLUT-4 translocation in response to insulin. These results emphasize the specific regulation of GLUT-4 in insulin-sensitive tissues.


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