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Am J Physiol Endocrinol Metab 271: E451-E457, 1996;
0193-1849/96 $5.00
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AJP - Endocrinology and Metabolism, Vol 271, Issue 3 E451-E457, Copyright © 1996 by American Physiological Society

ARTICLES

Cobalt but not hypoxia stimulates PDGF gene expression in rats

M. Bucher, P. Sandner, K. Wolf and A. Kurtz
Institut fur Physiologie, Universitat Regensburg, Germany.

This study was done to investigate the influence of different forms of acute tissue hypoxia on the expression of platelet-derived growth factor (PDGF) A chain (PDGF-A) and PDGF B chain (PDGF-B) genes in different rat organs. We found that acute normobaric hypoxia (8% O2), carbon monoxide inhalation (0.1% CO), or lowering the hematocrit to 12% for 6 h had no effect on PDGF-A or PDGF-B gene expression in lung, heart, kidney, and liver of Sprague-Dawley rats. Subcutaneous administration of cobaltous chloride dose dependently increased PDGF-B mRNA by 125% in lungs, by 60% in kidneys, but not in heart and liver. These findings suggest that acute tissue hypoxygenation is not a significant stimulus for PDGF-A and PDGF-B gene expression in these major rat organs. Cobalt appears to cause a tissue-specific increase of PDGF-B gene expression.


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 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K.-H. Hofbauer, B. L. Jensen, A. Kurtz, and P. Sandner
Tissue hypoxygenation activates the adrenomedullin system in vivo
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2000; 278(2): R513 - R519.
[Abstract] [Full Text] [PDF]


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