AJP - Endo Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 271: E326-E332, 1996;
0193-1849/96 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Marshall, S. M.
Right arrow Articles by Flyvbjerg, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Marshall, S. M.
Right arrow Articles by Flyvbjerg, A.

AJP - Endocrinology and Metabolism, Vol 271, Issue 2 E326-E332, Copyright © 1996 by American Physiological Society

ARTICLES

Effects of heparin on renal morphology and albuminuria in experimental diabetes

S. M. Marshall, K. W. Hansen, R. Osterby, J. Frystyk, H. Orskov and A. Flyvbjerg
Institute of Experimental Clinical Research, University of Aarhus, Denmark.

Female nondiabetic and streptozotocin diabetic Wistar rats received 200 units heparin two times daily by subcutaneous injection for 6 mo. Mesangial volume fraction was reduced in heparin-treated control (CH) compared with untreated control (C) animals (CH 0.18 +/- 0.02 vs. C 0.24 +/- 0.02, P < 0.05), but other histological parameters were similar. In the heparin-treated diabetic (DH) group, wet kidney weight was increased compared with the untreated diabetic (D) group (DH 1,156 +/- 39 vs. D 1,050 +/- 30 mg, P < 0.05), as were absolute, but not fractional, glomerular volume (P < 0.05) and capillary volume (P < 0.05). Basement membrane thickness (DH 193 +/- 3 vs. D 231 +/- 9 nm, P < 0.01) and mesangial/glomerular volume fraction (P < 0.001) were decreased. Urinary albumin excretion was increased in the heparin-treated control animals compared with control animals [CH 980 (range 150-4,448) vs. C 221 (range 86-654) micrograms/24 h, P < 0.001] and in the heparin-treated diabetic animals compared with the diabetic animals [DH 12,785 (range 4,495-29,520) vs. D 899 (range 450-1,335) micrograms/24 h, P < 0.001]. Thus the possibly deleterious increases in glomerular capillary volume and albumin excretion may negate the beneficial effects of heparin on mesangial and basement membrane structures.


This article has been cited by other articles:


Home page
 J. Am. Soc. Nephrol.Home page
M. CEOL, G. GAMBARO, U. SAUER, B. BAGGIO, F. ANGLANI, M. FORINO, S. FACCHIN, L. BORDIN, C. WEIGERT, A. NERLICH, et al.
Glycosaminoglycan Therapy Prevents TGF-{beta}1 Overexpression and Pathologic Changes in Renal Tissue of Long-Term Diabetic Rats
J. Am. Soc. Nephrol., December 1, 2000; 11(12): 2324 - 2336.
[Abstract] [Full Text]

Home page
 J. Am. Soc. Nephrol.Home page
G. GAMBARO and F. J. VAN DER WOUDE
Glycosaminoglycans: Use in Treatment of DiabeticNephropathy
J. Am. Soc. Nephrol., February 1, 2000; 11(2): 359 - 368.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
G. G. B. Baggio;, S. M. Marshall, K. W. Hansen, R. Osterby, J. Frystyk, H. Orskov, and A. Flyvbjerg
Letters to the Editor
Am J Physiol Endocrinol Metab, January 1, 1998; 274(1): E192 - E193.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online