AJP - Endo Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 270: E621-E626, 1996;
0193-1849/96 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cooney, R. N.
Right arrow Articles by Vary, T. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cooney, R. N.
Right arrow Articles by Vary, T. C.

AJP - Endocrinology and Metabolism, Vol 270, Issue 4 E621-E626, Copyright © 1996 by American Physiological Society

ARTICLES

Prevention of skeletal muscle catabolism in sepsis does not impair visceral protein metabolism

R. N. Cooney, E. Owens, D. Slaymaker and T. C. Vary
Department of Surgery, Pennsylvania State University, College of Medicine, Hershey 17033, USA.

We investigated whether the preservation of gastrocnemius proteins by interleukin-1 receptor antagonist (IL-1ra) during sepsis altered protein metabolism in visceral tissues. Sepsis was induced by creation of an abdominal abscess followed by infusion of saline of IL-1ra. Five days later, the tissue protein content and rate of protein synthesis were measured. IL-1ra did not significantly alter hepatic protein metabolism in septic or control animals. In kidney, the protein content and rate of protein synthesis were both decreased by sepsis and significantly ameliorated by the infusion of IL-1ra. Sepsis decreased the rate of protein synthesis in the small intestine. IL-1ra increased intestinal protein synthesis in both control and septic animals; however, the effects were localized to the seromuscular layer. The preservation of muscle protein by IL-1ra in sepsis did not adversely affect protein synthesis in any of the visceral tissues examined. IL-1 appears to mediate the sepsis-induced changes in protein synthesis in kidney and small intestine but not in liver or spleen. Protein synthesis in each visceral organ responds differently to the septic insult and modulation of IL-1 bioactivity.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
R. A. Orellana, A. Jeyapalan, J. Escobar, J. W. Frank, H. V. Nguyen, A. Suryawan, and T. A. Davis
Amino acids augment muscle protein synthesis in neonatal pigs during acute endotoxemia by stimulating mTOR-dependent translation initiation
Am J Physiol Endocrinol Metab, November 1, 2007; 293(5): E1416 - E1425.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
M. J. Bruins, P. B. Soeters, and N. E. P. Deutz
Endotoxemia Affects Organ Protein Metabolism Differently during Prolonged Feeding in Pigs
J. Nutr., December 1, 2000; 130(12): 3003 - 3013.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
O. Mansoor, M. Cayol, P. Gachon, Y. Boirie, P. Schoeffler, C. Obled, and B. Beaufrere
Albumin and fibrinogen syntheses increase while muscle protein synthesis decreases in head-injured patients
Am J Physiol Endocrinol Metab, November 1, 1997; 273(5): E898 - E902.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online