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AJP - Endocrinology and Metabolism, Vol 270, Issue 3 E375-E385, Copyright © 1996 by American Physiological Society
ARTICLES |
A. R. Saltiel
Department of Signal Transduction, Parke-Davis Pharmaceutical Research, Warner-Lambert, Ann Arbor, Michigan 48105, USA.
Insulin is one of the most important regulators of glucose and lipid homeostasis. Many of its cellular actions are mediated by changes in protein phosphorylation. The consequences of these phosphorylation events extend from a series of different short-term metabolic actions to longer-term effects of the hormone on cellular growth and differentiation. Although the insulin receptor itself is a tyrosine kinase that is activated upon hormone binding, the ensuing changes in phosphorylation occur predominantly on serine and threonine residues. Moreover, insulin can simultaneously stimulate the phosphorylation of some proteins and the dephosphorylation of others. These paradoxical effects of insulin suggest that separate signal transduction pathways may emanate from the receptor itself to produce the pleiotropic actions of the hormone.
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