AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 270: E148-E157, 1996;
0193-1849/96 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brodsky, I. G.
Right arrow Articles by Devlin, J. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brodsky, I. G.
Right arrow Articles by Devlin, J. T.

AJP - Endocrinology and Metabolism, Vol 270, Issue 1 E148-E157, Copyright © 1996 by American Physiological Society

ARTICLES

Effects of dietary protein restriction on regional amino acid metabolism in insulin-dependent diabetes mellitus

I. G. Brodsky and J. T. Devlin
Metabolic Unit, University of Vermont, Burlington 05405, USA.

We studied subjects with insulin-dependent diabetes mellitus (IDDM) and controls by administering primed continuous infusions of L-[1-13C,15N)]leucine and L-[2,3-13C2]alanine to measure whole body and forearm metabolism of these amino acids during ample protein intake and again after 4 wk of moderately restricted protein intake. Decreased rates of whole body protein degradation, leucine transamination, leucine oxidation, and increased forearm alanine release produced by dietary protein restriction occurred equivalently in IDDM subjects under short-term tightly managed glycemia and in controls. Dietary protein restriction did not affect whole body alanine appearance or forearm leucine appearance, disposal, or balance in IDDM subjects or controls. IDDM subjects differed from controls only in that normal forearm leucine balance was maintained at higher rates of leucine appearance and disposal. We conclude that IDDM subjects adapt normally to dietary protein restriction. Undernutrition during moderate protein deprivation in these patients likely occurs during episodes of poor glycemic control.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
S. Walrand, K. R. Short, M. L. Bigelow, A. J. Sweatt, S. M. Hutson, and K. S. Nair
Functional impact of high protein intake on healthy elderly people
Am J Physiol Endocrinol Metab, October 1, 2008; 295(4): E921 - E928.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
M. J. Franz, J. P. Bantle, C. A. Beebe, J. D. Brunzell, J.-L. Chiasson, A. Garg, L. A. Holzmeister, B. Hoogwerf, E. Mayer-Davis, A. D. Mooradian, et al.
Evidence-Based Nutrition Principles and Recommendations for the Treatment and Prevention of Diabetes and Related Complications
Diabetes Care, January 1, 2002; 25(1): 148 - 198.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
W. A. El-Harake, M. A. Furman, B. Cook, K. S. Nair, J. Kukowski, and I. G. Brodsky
Measurement of dermal collagen synthesis rate in vivo in humans
Am J Physiol Endocrinol Metab, April 1, 1998; 274(4): E586 - E591.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
I. G. Brodsky
Nutritional Effects of Dietary Protein Restriction in Insulin-Dependent Diabetes Mellitus
J. Nutr., February 1, 1998; 128(2): 337 - 337.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online