AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 269: E827-E833, 1995;
0193-1849/95 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Colomb, V.
Right arrow Articles by Girard, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Colomb, V.
Right arrow Articles by Girard, J.

AJP - Endocrinology and Metabolism, Vol 269, Issue 5 E827-E833, Copyright © 1995 by American Physiological Society

ARTICLES

Route of nutrient delivery affects insulin sensitivity and liver glucose transporter expression in rat

V. Colomb, A. Leturque, G. Guihot, M. Loizeau, S. Lavie, S. Colomer, C. Ricour and J. Girard
Centre de Recherche sur l'Endocrinologie Moleculaire et le Developpement, Centre National de la Recherche Scientifique, Meudon-Bellevue, France.

To optimize artificial nutrition (AN) techniques for patients suffering from malnutrition or reduced intestinal absorption, utilization of energy fuels, especially glucose, requires better understanding. Because the liver plays a key role in glucose homeostasis, the aim of this study was to assess the effects of continuous intragastric and intravenous nutrition on insulin secretion and several markers of liver glucose metabolism, especially glucose transporter GLUT-2. Wistar male rats underwent catheterization of either stomach (intragastric) or vena cava (intravenous) and received 24 h/day the same all-in-one formula over 7 to 14 days. The metabolic parameters from intragastrically fed rats did not differ significantly from those from orally fed control rats. Intravenous nutrition induced insulin resistance (marked hyperinsulinemia and/or mild hyperglycemia) and reduced liver GLUT-2 protein and mRNA levels. The decrease in liver GLUT-2 gene expression might be mediated either by an inhibitory role of hyperinsulinemia or by the decrease in gut or portal factors. These results suggest that the route of nutrient delivery influences their utilization by the liver.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
S. Osowska, T. Duchemann, S. Walrand, A. Paillard, Y. Boirie, L. Cynober, and C. Moinard
Citrulline modulates muscle protein metabolism in old malnourished rats
Am J Physiol Endocrinol Metab, September 1, 2006; 291(3): E582 - E586.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. Vella, P. Shah, R. Basu, A. Basu, M. Camilleri, W. F. Schwenk, and R. A. Rizza
Effect of enteral vs. parenteral glucose delivery on initial splanchnic glucose uptake in nondiabetic humans
Am J Physiol Endocrinol Metab, August 1, 2002; 283(2): E259 - E266.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online