AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 269: E820-E826, 1995;
0193-1849/95 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Urban, R. J.
Right arrow Articles by Ferrando, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Urban, R. J.
Right arrow Articles by Ferrando, A.

AJP - Endocrinology and Metabolism, Vol 269, Issue 5 E820-E826, Copyright © 1995 by American Physiological Society

ARTICLES

Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis

R. J. Urban, Y. H. Bodenburg, C. Gilkison, J. Foxworth, A. R. Coggan, R. R. Wolfe and A. Ferrando
Department of Internal Medicine, University of Texas Medical Branch Galveston 77555-1060, USA.

Aging men develop a significant loss of muscle strength that occurs in conjunction with a decline in serum testosterone concentrations. We investigated the effects of testosterone administration to six healthy men [67 +/- 2 (SE) yr] on skeletal muscle protein synthesis, strength, and the intramuscular insulin-like growth factor I (IGF-I) system. Elderly men with serum testosterone concentrations of 480 ng/dl or less were given testosterone injections for 4 wk to produce serum concentrations equal to those of younger men. During testosterone administration muscle strength (isokinetic dynamometer) increased in both right and left hamstring and quadricep muscles as did the fractional synthetic rate of muscle protein (stable-isotope infusion). Ribonuclease protection assays done on total RNA from muscle showed that testosterone administration increased mRNA concentrations of IGF-I and decreased mRNA concentrations of insulin-like growth factor binding protein-4. We conclude that increasing testosterone concentrations in elderly men increases skeletal muscle protein synthesis and strength. This increase may be mediated by stimulation of the intramuscular IGF-I system.


This article has been cited by other articles:


Home page
 Clin TrialsHome page
E. T. Schroeder, C. Castaneda-Sceppa, Ying Wang, E. F. Binder, M. Kawakubo, Y. Stewart, T. Storer, R. Roubenoff, S. Bhasin, K. E. Yarasheski, et al.
Hormonal regulators of muscle and metabolism in aging (HORMA): design and conduct of a complex, double masked multicenter trial
Clinical Trials, October 1, 2007; 4(5): 560 - 571.
[Abstract] [PDF]

Home page
 J. Appl. Physiol.Home page
M. I. Lewis, M. Fournier, T. W. Storer, S. Bhasin, J. Porszasz, S.-G. Ren, X. Da, and R. Casaburi
Skeletal muscle adaptations to testosterone and resistance training in men with COPD
J Appl Physiol, October 1, 2007; 103(4): 1299 - 1310.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
S. D. R. Harridge
Plasticity of human skeletal muscle: gene expression to in vivo function
Exp Physiol, September 1, 2007; 92(5): 783 - 797.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
K. Aizawa, M. Iemitsu, S. Maeda, S. Jesmin, T. Otsuki, C. N. Mowa, T. Miyauchi, and N. Mesaki
Expression of steroidogenic enzymes and synthesis of sex steroid hormones from DHEA in skeletal muscle of rats
Am J Physiol Endocrinol Metab, February 1, 2007; 292(2): E577 - E584.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
D. T. Villareal and J. O. Holloszy
DHEA enhances effects of weight training on muscle mass and strength in elderly women and men
Am J Physiol Endocrinol Metab, November 1, 2006; 291(5): E1003 - E1008.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. J. Toth, C. K. Sites, D. E. Matthews, and P. R. Casson
Ovarian suppression with gonadotropin-releasing hormone agonist reduces whole body protein turnover in women
Am J Physiol Endocrinol Metab, September 1, 2006; 291(3): E483 - E490.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
T. Munzer, C. J. Rosen, S.M. Harman, K. M. Pabst, C. St. Clair, J. D. Sorkin, and M. R. Blackman
Effects of GH and/or sex steroids on circulating IGF-I and IGFBPs in healthy, aged women and men
Am J Physiol Endocrinol Metab, May 1, 2006; 290(5): E1006 - E1013.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
E. T. Schroeder, A. F. Vallejo, L. Zheng, Y. Stewart, C. Flores, S. Nakao, C. Martinez, and F. R. Sattler
Six-Week Improvements in Muscle Mass and Strength During Androgen Therapy in Older Men
J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2005; 60(12): 1586 - 1592.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. M. McClung, K. A. Mehl, R. W. Thompson, L. L. Lowe, and J. A. Carson
Nandrolone decanoate modulates cell cycle regulation in functionally overloaded rat soleus muscle
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1543 - R1552.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
A Cremades, C Ruzafa, F Monserrat, A J Lopez-Contreras, and R Penafiel
Influence of dietary arginine on the anabolic effects of androgens
J. Endocrinol., November 1, 2004; 183(2): 343 - 351.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. Casaburi, S. Bhasin, L. Cosentino, J. Porszasz, A. Somfay, M. I. Lewis, M. Fournier, and T. W. Storer
Effects of Testosterone and Resistance Training in Men with Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., October 15, 2004; 170(8): 870 - 878.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. T. Schroeder, L. Zheng, K. E. Yarasheski, D. Qian, Y. Stewart, C. Flores, C. Martinez, M. Terk, and F. R. Sattler
Treatment with oxandrolone and the durability of effects in older men
J Appl Physiol, March 1, 2004; 96(3): 1055 - 1062.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
S. Bhasin, W. E. Taylor, R. Singh, J. Artaza, I. Sinha-Hikim, R. Jasuja, H. Choi, and N. F. Gonzalez-Cadavid
The Mechanisms of Androgen Effects on Body Composition: Mesenchymal Pluripotent Cell as the Target of Androgen Action
J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2003; 58(12): M1103 - 1110.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. J. Doherty
Invited Review: Aging and sarcopenia
J Appl Physiol, October 1, 2003; 95(4): 1717 - 1727.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
E. T. Schroeder, M. Terk, and F. R. Sattler
Androgen therapy improves muscle mass and strength but not muscle quality: results from two studies
Am J Physiol Endocrinol Metab, July 1, 2003; 285(1): E16 - E24.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
I. Sinha-Hikim, S. M. Roth, M. I. Lee, and S. Bhasin
Testosterone-induced muscle hypertrophy is associated with an increase in satellite cell number in healthy, young men
Am J Physiol Endocrinol Metab, July 1, 2003; 285(1): E197 - E205.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
L. J. Woodhouse, S. Reisz-Porszasz, M. Javanbakht, T. W. Storer, M. Lee, H. Zerounian, and S. Bhasin
Development of models to predict anabolic response to testosterone administration in healthy young men
Am J Physiol Endocrinol Metab, May 1, 2003; 284(5): E1009 - E1017.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
W. J. Lee, J. McClung, G. A. Hand, and J. A. Carson
Overload-induced androgen receptor expression in the aged rat hindlimb receiving nandrolone decanoate
J Appl Physiol, March 1, 2003; 94(3): 1153 - 1161.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
M. M. Bamman, V. J. Hill, G. R. Adams, F. Haddad, C. J. Wetzstein, B. A. Gower, A. Ahmed, and G. R. Hunter
Gender Differences in Resistance-Training-Induced Myofiber Hypertrophy Among Older Adults
J. Gerontol. A Biol. Sci. Med. Sci., February 1, 2003; 58(2): B108 - 116.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
E. T. Schroeder, A. Singh, S. Bhasin, T. W. Storer, C. Azen, T. Davidson, C. Martinez, I. Sinha-Hikim, S. V. Jaque, M. Terk, et al.
Effects of an oral androgen on muscle and metabolism in older, community-dwelling men
Am J Physiol Endocrinol Metab, January 1, 2003; 284(1): E120 - E128.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
M. Iannuzzi-Sucich, K. M. Prestwood, and A. M. Kenny
Prevalence of Sarcopenia and Predictors of Skeletal Muscle Mass in Healthy, Older Men and Women
J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2002; 57(12): M772 - 777.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
F. R. Sattler, E. T. Schroeder, M. P. Dube, S. V. Jaque, C. Martinez, P. J. Blanche, S. Azen, and R. M. Krauss
Metabolic effects of nandrolone decanoate and resistance training in men with HIV
Am J Physiol Endocrinol Metab, December 1, 2002; 283(6): E1214 - E1222.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Coll. Nutr.Home page
G. A. Brown, M. D. Vukovich, E. R. Martini, M. L. Kohut, W. D. Franke, D. A. Jackson, and D. S. King
Endocrine and Lipid Responses to Chronic Androstenediol-Herbal Supplementation in 30 to 58 Year Old Men
J. Am. Coll. Nutr., October 1, 2002; 20(5): 520 - 528.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
T. A. Roy, M. R. Blackman, S. M. Harman, J. D. Tobin, M. Schrager, and E. J. Metter
Interrelationships of serum testosterone and free testosterone index with FFM and strength in aging men
Am J Physiol Endocrinol Metab, August 1, 2002; 283(2): E284 - E294.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. A. Carson, W. J. Lee, J. McClung, and G. A. Hand
Steroid receptor concentration in aged rat hindlimb muscle: effect of anabolic steroid administration
J Appl Physiol, July 1, 2002; 93(1): 242 - 250.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
A. M. Kenny, K. M. Prestwood, C. A. Gruman, G. Fabregas, B. Biskup, and G. Mansoor
Effects of Transdermal Testosterone on Lipids and Vascular Reactivity in Older Men With Low Bioavailable Testosterone Levels
J. Gerontol. A Biol. Sci. Med. Sci., July 1, 2002; 57(7): M460 - 465.
[Abstract] [Full Text]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
A. M. Matsumoto
Andropause: Clinical Implications of the Decline in Serum Testosterone Levels With Aging in Men
J. Gerontol. A Biol. Sci. Med. Sci., February 1, 2002; 57(2): M76 - 99.
[Full Text]

Home page
 Recent Prog Horm ResHome page
C. M. Kuhn
Anabolic Steroids
Recent Prog. Horm. Res., January 1, 2002; 57(1): 411 - 434.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
T. J. Marcell, S. M. Harman, R. J. Urban, D. D. Metz, B. D. Rodgers, and M. R. Blackman
Comparison of GH, IGF-I, and testosterone with mRNA of receptors and myostatin in skeletal muscle in older men
Am J Physiol Endocrinol Metab, December 1, 2001; 281(6): E1159 - E1164.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
J. E. Morley
Editorial: Andropause: Is It Time for the Geriatrician to Treat It?
J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2001; 56(5): 263M - 265.
[Full Text]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
A. M. Kenny, K. M. Prestwood, C. A. Gruman, K. M. Marcello, and L. G. Raisz
Effects of Transdermal Testosterone on Bone and Muscle in Older Men With Low Bioavailable Testosterone Levels
J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2001; 56(5): 266M - 272.
[Abstract] [Full Text]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
M.-M. G. Wilson
Guest Editorial: Bitter-Sweet Memories: Truth and Fiction
J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2001; 56(4): 196M - 199.
[Full Text]

Home page
 J. Appl. Physiol.Home page
C. E. Blanco, W.-Z. Zhan, Y.-H. Fang, and G. C. Sieck
Exogenous testosterone treatment decreases diaphragm neuromuscular transmission failure in male rats
J Appl Physiol, March 1, 2001; 90(3): 850 - 856.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. M. Bamman, J. R. Shipp, J. Jiang, B. A. Gower, G. R. Hunter, A. Goodman, C. L. McLafferty Jr., and R. J. Urban
Mechanical load increases muscle IGF-I and androgen receptor mRNA concentrations in humans
Am J Physiol Endocrinol Metab, March 1, 2001; 280(3): E383 - E390.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
R. Roubenoff and V. A. Hughes
Sarcopenia: Current Concepts
J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2000; 55(12): 716M - 724.
[Abstract] [Full Text]

Home page
 QJMHome page
P.J. Pugh, K.M. English, T.H. Jones, and K.S. Channer
Testosterone: a natural tonic for the failing heart?
QJM, October 1, 2000; 93(10): 689 - 694.
[Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
S.-S. Yeh and M. W Schuster
Geriatric cachexia: the role of cytokines
Am. J. Clinical Nutrition, August 1, 1999; 70(2): 183 - 197.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease . A Statement of the American Thoracic Society and European Respiratory Society
Am. J. Respir. Crit. Care Med., April 1, 1999; 159(4): S2 - 40.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. I. Lewis, M. Fournier, A. Y. Yeh, P. E. Micevych, and G. C. Sieck
Alterations in diaphragm contractility after nandrolone administration: an analysis of potential mechanisms
J Appl Physiol, March 1, 1999; 86(3): 985 - 992.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. A. Farrell, M. J. Fedele, T. C. Vary, S. R. Kimball, and L. S. Jefferson
Effects of intensity of acute-resistance exercise on rates of protein synthesis in moderately diabetic rats
J Appl Physiol, December 1, 1998; 85(6): 2291 - 2297.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. A. Ferrando, K. D. Tipton, D. Doyle, S. M. Phillips, J. Cortiella, and R. R. Wolfe
Testosterone injection stimulates net protein synthesis but not tissue amino acid transport
Am J Physiol Endocrinol Metab, November 1, 1998; 275(5): E864 - E871.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
D. N. Proctor, P. Balagopal, and K. S. Nair
Age-Related Sarcopenia in Humans Is Associated with Reduced Synthetic Rates of Specific Muscle Proteins
J. Nutr., February 1, 1998; 128(2): 351 - 351.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
P. Balagopal, O. E. Rooyackers, D. B. Adey, P. A. Ades, and K. S. Nair
Effects of aging on in vivo synthesis of skeletal muscle myosin heavy-chain and sarcoplasmic protein in humans
Am J Physiol Endocrinol Metab, October 1, 1997; 273(4): E790 - E800.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. E. Morley, F. Kaiser, W. J. Raum, H. M. Perry III, J. F. Flood, J. Jensen, A. J. Silver, and E. Roberts
Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: Progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor 1 to growth hormone
PNAS, July 8, 1997; 94(14): 7537 - 7542.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. I. Lewis, G. D. Horvitz, D. R. Clemmons, and M. Fournier
Role of IGF-I and IGF-binding proteins within diaphragm muscle in modulating the effects of nandrolone
Am J Physiol Endocrinol Metab, February 1, 2002; 282(2): E483 - E490.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. A. Ferrando, M. Sheffield-Moore, C. W. Yeckel, C. Gilkison, J. Jiang, A. Achacosa, S. A. Lieberman, K. Tipton, R. R. Wolfe, and R. J. Urban
Testosterone administration to older men improves muscle function: molecular and physiological mechanisms
Am J Physiol Endocrinol Metab, March 1, 2002; 282(3): E601 - E607.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online