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Am J Physiol Endocrinol Metab 269: E723-E730, 1995;
0193-1849/95 $5.00
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AJP - Endocrinology and Metabolism, Vol 269, Issue 4 E723-E730, Copyright © 1995 by American Physiological Society

ARTICLES

Insulin regulates circulating insulin-like growth factors and some of their binding proteins in lactating cows

M. A. McGuire, D. A. Dwyer, R. J. Harrell and D. E. Bauman
Department of Animal Sciences, Cornell University, Ithaca, New York 14853, USA.

Four lactating Holstein cows were subjected to a hyperinsulinemic-euglycemic clamp to evaluate the effects of insulin on circulating concentrations of insulin-like growth factors (IGF) and their binding proteins (IGFBP). Baseline blood samples were taken every 4 h for 2 days. For the 4-day clamp, insulin was infused (1 microgram.kg body wt-1.h-1) into the jugular vein and exogenous glucose was infused to maintain euglycemia. Circulating insulin was increased approximately fivefold, while glucose was maintained within 10% of baseline concentrations by infusion of 0.15 g.kg body wt-1.h-1 glucose. Hyperinsulinemia-euglycemia approximately doubled IGF-I (145 vs. 286 ng/ml, SE = 20) while decreasing circulating IGF-II (285 vs. 180 ng/ml, SE = 32). Densitometry of Western blots demonstrated no change in IGFBP-3 or a 30,000 relative molecular weight (M(r)) band during the clamp. However, IGFBP-2 decreased 73% and a 26,000 M(r) band decreased 58% by the end of the clamp. Therefore, insulin, directly or via secondary changes, increased circulating concentrations of IGF-I while decreasing concentrations of IGF-II, IGFBP-2, and a 26,000 M(r) IGFBP in lactating cows.


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