AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 269: E538-E550, 1995;
0193-1849/95 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ryan, C.
Right arrow Articles by Radziuk, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ryan, C.
Right arrow Articles by Radziuk, J.

AJP - Endocrinology and Metabolism, Vol 269, Issue 3 E538-E550, Copyright © 1995 by American Physiological Society

ARTICLES

Distinguishable substrate pools for muscle glyconeogenesis in lactate-supplemented recovery from exercise

C. Ryan and J. Radziuk
Ottawa Civic Hospital, Ontario, Canada.

The formation of muscle glycogen from substrates other than glucose (glyconeogenesis) has now been demonstrated 1) from circulating lactate when this lactate is elevated and 2) from intramuscular substrate, which equilibrates with the products of local glucose metabolism but not with circulating lactate [Am. J. Physiol. 267 (Endocrinol. Metab. 30): E210-E218, 1994]. The purpose of the present studies was to examine the interaction of recovery from low-intensity exercise (4-h swim) and supplementation with exogenous lactate in determining the distribution of carbon flux between these two pathways for the glyconeogenic process in the gastrocnemius muscles. Ten protocols were defined using [14C]bicarbonate (no local incorporation into glycogen), [U-14C]lactate (tracks circulating lactate), and recycled [1-14C]glucose (tracks local substrate formation and glyconeogenesis). During recovery, lactate was infused to increase circulating concentrations 15- to 20-fold. Glucose and saline infusions during recovery were used as controls. The results indicate that prior exercise primarily promotes the local incorporation of recycled glucose label produced within the muscle into glycogen. Exogenous lactate stimulates the incorporation of circulating lactate into muscle glycogen. The contribution of the two substrate pools to glycogen synthesis appears to be additive, indicating the independence of muscle glycogenesis from these two sources.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
T. B. Price, D. Laurent, K. F. Petersen, D. L. Rothman, and G. I. Shulman
Glycogen loading alters muscle glycogen resynthesis after exercise
J Appl Physiol, February 1, 2000; 88(2): 698 - 704.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. Pagano, M. Granzotto, A. Giaccari, R. Fabris, R. Serra, A. M. Lombardi, G. Federspil, and R. Vettor
Lactate infusion to normal rats during hyperglycemia enhances in vivo muscle glycogen synthesis
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 1997; 273(6): R2072 - R2079.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online