AJP - Endocrinology and Metabolism, Vol 269, Issue 2 E368-E376, Copyright © 1995 by American Physiological Society

ARTICLES

Simultaneous treatment with IGF-I and GH additively increases anabolism in parenterally fed rats

H. C. Lo, P. S. Hinton, C. A. Peterson and D. M. Ney
Department of Nutritional Sciences, University of Wisconsin-Madison 53706, USA.

We compared the effects of recombinant human insulin-like growth factor I [rhIGF-I, 800 micrograms/day, coinfused with total parenteral nutrition (TPN)], growth hormone (rhGH, 800 micrograms/day, subcutaneous injection twice daily), and simultaneous treatment with rhIGF-I and rhGH (800 + 800 micrograms/day) in rats subjected to surgical stress and maintained with TPN. Weight gain induced by IGF-I plus GH was double that shown by IGF-I or GH alone. Although weight gain was similar with IGF-I or GH, IGF-I selectively increased heart, kidney, thymus, spleen, and small intestine mass, whereas GH selectively increased gastrocnemius muscle mass. IGF-I and/or GH increased carcass protein and water while decreasing fat. Serum total and free IGF-I levels were highest with IGF-I plus GH. Serum rat GH levels were reduced with IGF-I and/or GH. IGF-I given with GH reversed the GH-induced increase in serum insulin. In summary, IGF-I and GH show tissue-specific anabolic effects, and simultaneous treatment with IGF-I plus GH additively increases anabolism during TPN.

This article has been cited by other articles:

				M. B. Gillingham, E. M. Dahly, S. G. Murali, and D. M. Ney IGF-I treatment facilitates transition from parenteral to enteral nutrition in rats with short bowel syndrome Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2003; 284(2): R363 - R371. [Abstract] [Full Text] [PDF]

				M. B. Gillingham, K. R. Kritsch, S. G. Murali, P. K. Lund, and D. M. Ney Resection upregulates the IGF-I system of parenterally fed rats with jejunocolic anastomosis Am J Physiol Gastrointest Liver Physiol, November 1, 2001; 281(5): G1158 - G1168. [Abstract] [Full Text] [PDF]

				A. Sevette, A. J. Kee, A. R. Carlsson, R. C. Baxter, and R. C. Smith Parenteral nutrition with lipid or glucose suppresses liver growth and response to GH in adolescent male rats Am J Physiol Endocrinol Metab, November 1, 2001; 281(5): E1063 - E1072. [Abstract] [Full Text] [PDF]

				M. B. Gillingham, E. M. Dahly, H. V. Carey, M. D. Clark, K. R. Kritsch, and D. M. Ney Differential jejunal and colonic adaptation due to resection and IGF-I in parenterally fed rats Am J Physiol Gastrointest Liver Physiol, May 1, 2000; 278(5): G700 - G709. [Abstract] [Full Text] [PDF]

				A. J. Kee, R. C. Baxter, A. R. Carlsson, and R. C. Smith Parenteral amino acid intake alters the anabolic actions of insulin-like growth factor I in rats Am J Physiol Endocrinol Metab, July 1, 1999; 277(1): E63 - E72. [Abstract] [Full Text] [PDF]

				X.-J. Zhang, D. L. Chinkes, S. E. Wolf, and R. R. Wolfe Insulin but not growth hormone stimulates protein anabolism in skin wound and muscle Am J Physiol Endocrinol Metab, April 1, 1999; 276(4): E712 - E720. [Abstract] [Full Text] [PDF]

				M. I. Lewis, A. T. Feinberg, and M. Fournier IGF-I and/or growth hormone preserve diaphragm fiber size with moderate malnutrition J Appl Physiol, July 1, 1998; 85(1): 189 - 197. [Abstract] [Full Text] [PDF]

				G. E. McCall, D. L. Allen, J. K. Linderman, R. E. Grindeland, R. R. Roy, V. R. Mukku, and V. R. Edgerton Maintenance of myonuclear domain size in rat soleus after overload and growth hormone/IGF-I treatment J Appl Physiol, April 1, 1998; 84(4): 1407 - 1412. [Abstract] [Full Text] [PDF]

				M. I. Lewis, T. J. Lorusso, and M. Fournier Anabolic influences of insulin-like growth factor I and/or growth hormone on the diaphragm of young rats J Appl Physiol, June 1, 1997; 82(6): 1972 - 1978. [Abstract] [Full Text] [PDF]

				M. I. Lewis, T. J. Lorusso, and M. Fournier Effect of insulin-like growth factor I and/or growth hormone on diaphragm of malnourished adolescent rats J Appl Physiol, April 1, 1997; 82(4): 1064 - 1070. [Abstract] [Full Text] [PDF]