AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 268: E735-E744, 1995;
0193-1849/95 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Smith, C. B.
Right arrow Articles by Sun, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Smith, C. B.
Right arrow Articles by Sun, Y.

AJP - Endocrinology and Metabolism, Vol 268, Issue 4 E735-E744, Copyright © 1995 by American Physiological Society

ARTICLES

Influence of valine flooding on channeling of valine into tissue pools and on protein synthesis

C. B. Smith and Y. Sun
Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland 20892, USA.

Rates of valine incorporation into protein were measured under control and valine-"flooding" conditions and included correction for the degree of recycling of unlabeled valine derived from the steady-state breakdown of tissue protein into the precursor pool (tRNA bound). The correction factor lambda, which is the ratio of the steady-state specific activity of valine in the tissue tRNA-bound pool to that in the arterial plasma, was determined for each of the tissues. In controls, values of lambda ranged from 0.31 in adrenals to 0.54 in heart; in flooded animals, values were higher, but only in liver was the value of lambda close to 1.0. In control and flooded rats, rates of protein synthesis were highest in liver and adrenals and lowest in skeletal muscle, with intermediate values in brain and heart. Flooding resulted in increased rates of protein synthesis in liver and decreased rates in adrenals. Rates of protein synthesis in brain, heart, and skeletal muscle were not statistically significantly affected by flooding.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
B.-M. Iresjo, E. Svanberg, and K. Lundholm
Reevaluation of amino acid stimulation of protein synthesis in murine- and human-derived skeletal muscle cells assessed by independent techniques
Am J Physiol Endocrinol Metab, May 1, 2005; 288(5): E1028 - E1037.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. M. Veeneman, H. A. Kingma, T. S. Boer, F. Stellaard, P. E. De Jong, D.-J. Reijngoud, and R. M. Huisman
Protein intake during hemodialysis maintains a positive whole body protein balance in chronic hemodialysis patients
Am J Physiol Endocrinol Metab, May 1, 2003; 284(5): E954 - E965.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
H. A. Johnson, R. L. Baldwin, K. C. Klasing, J. France, and C. C. Calvert
A Rodent Model of Protein Turnover Used to Design an Experiment for Measuring the Rates of Channeling, Recycling and Protein Synthesis
J. Nutr., December 1, 2000; 130(12): 3097 - 3102.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. B. Smith and J. Kang
Cerebral protein synthesis in a genetic mouse model of phenylketonuria
PNAS, September 26, 2000; 97(20): 11014 - 11019.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
T. A. Davis, M. L. Fiorotto, H. V. Nguyen, and D. G. Burrin
Aminoacyl-tRNA and tissue free amino acid pools are equilibrated after a flooding dose of phenylalanine
Am J Physiol Endocrinol Metab, July 1, 1999; 277(1): E103 - E109.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online