| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Endocrinology and Metabolism, Vol 268, Issue 4 E705-E711, Copyright © 1995 by American Physiological Society
ARTICLES |
P. R. Vaughn, C. Lobo, F. C. Battaglia, P. V. Fennessey, R. B. Wilkening and G. Meschia
Department of Pediatrics, University of Colorado School of Medicine, Denver 80262, USA.
The hypothesis that glutamine shuttles nitrogen between placenta and fetal liver via interconversion with glutamate was explored by infusing L-[1,2-13C2]glutamine in six fetal sheep chronically catheterized for sampling of the umbilical and hepatic circulations. Fetal plasma glutamine disposal rate was 19.9 +/- 1.3 mumol.min-1.kg fetus-1. Entry of glutamine from the placenta accounted for approximately 60% of the total glutamine entry rate in fetal plasma. Glutamine was taken up by fetal liver, and 45.3 +/- 7.9% of the glutamine taken up was released as glutamate. The fetal liver released large quantities of glutamate, as evidenced by a sixfold increase in plasma glutamate concentration in the blood flowing through the left hepatic lobe and a hepatic glutamate output-to-O2 uptake molar ratio of 0.149 +/- 0.013. In conjunction with a previous study of fetal glutamate metabolism, these data demonstrate that glutamine entering the fetal circulation is converted to glutamate by the fetal liver at a rate of approximately 3-4 mumol.min-1.kg fetus-1.
This article has been cited by other articles:
|
|
 |
|
  F H Bloomfield, M H Oliver, and J E Harding The late effects of fetal growth patterns. Arch. Dis. Child. Fetal Neonatal Ed., July 1, 2006; 91(4): F299 - F304. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Timmerman, R.B. Wilkening, and T.R.H. Regnault Induction of Glutamate Dehydrogenase in the Ovine Fetal Liver by Dexamethasone Infusion during Late Gestation Experimental Biology and Medicine, January 1, 2003; 228(1): 100 - 105. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Teng, F. C. Battaglia, G. Meschia, M. R. Narkewicz, and R. B. Wilkening Fetal hepatic and umbilical uptakes of glucogenic substrates during a glucagon-somatostatin infusion Am J Physiol Endocrinol Metab, March 1, 2002; 282(3): E542 - E550. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Cramer, M. Beveridge, M. Kilberg, and D. Novak Physiological importance of system A-mediated amino acid transport to rat fetal development Am J Physiol Cell Physiol, January 1, 2002; 282(1): C153 - C160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Novak, F. Quiggle, C. Artime, and M. Beveridge Regulation of glutamate transport and transport proteins in a placental cell line Am J Physiol Cell Physiol, September 1, 2001; 281(3): C1014 - C1022. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C Kalhan Protein metabolism in pregnancy Am. J. Clinical Nutrition, May 1, 2000; 71(5): 1249S - 1255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Timmerman, C. Teng, R. B. Wilkening, P. Fennessey, F. C. Battaglia, and G. Meschia Effect of dexamethasone on fetal hepatic glutamine-glutamate exchange Am J Physiol Endocrinol Metab, May 1, 2000; 278(5): E839 - E845. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. C. Battaglia Glutamine and Glutamate Exchange between the Fetal Liver and the Placenta J. Nutr., April 1, 2000; 130(4): 974 - 974. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. A. Hediger and T. C. Welbourne Introduction: Glutamate transport, metabolism, and physiological responses Am J Physiol Renal Physiol, October 1, 1999; 277(4): F477 - F480. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Jauniaux, B. Gulbis, and E. Gerloo Free amino acids in human fetal liver and fluids at 12–17 weeks of gestation Hum. Reprod., June 1, 1999; 14(6): 1638 - 1641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Wu, T. L. Ott, D. A. Knabe, and F. W. Bazer Amino Acid Composition of the Fetal Pig J. Nutr., May 1, 1999; 129(5): 1031 - 1038. [Abstract] [Full Text]
|
|
|
|
|
|
G. Wu, W. G. Pond, T. Ott, and F. W. Bazer Maternal Dietary Protein Deficiency Decreases Amino Acid Concentrations in Fetal Plasma and Allantoic Fluid of Pigs J. Nutr., May 1, 1998; 128(5): 894 - 902. [Abstract] [Full Text]
|
|
|
|
|
|
J. C. Matthews, M. J. Beveridge, M. S. Malandro, J. D. Rothstein, M. Campbell-Thompson, J. W. Verlander, M. S. Kilberg, and D. A. Novak Activity and protein localization of multiple glutamate transporters in gestation day 14 vs. day 20 rat placenta Am J Physiol Cell Physiol, March 1, 1998; 274(3): C603 - C614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Chung, C. Teng, M. Timmerman, G. Meschia, and F. C. Battaglia Production and utilization of amino acids by ovine placenta in vivo Am J Physiol Endocrinol Metab, January 1, 1998; 274(1): E13 - E22. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-J. Fei, M. Sugawara, T. Nakanishi, W. Huang, H. Wang, P. D. Prasad, F. H. Leibach, and V. Ganapathy Primary Structure, Genomic Organization, and Functional and Electrogenic Characteristics of Human System N 1, a Na+- and H+-coupled Glutamine Transporter J. Biol. Chem., July 28, 2000; 275(31): 23707 - 23717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. Parimi, S. Devapatla, L. Gruca, A. M. O'Brien, R. W. Hanson, and S. C. Kalhan Glutamine and leucine nitrogen kinetics and their relation to urea nitrogen in newborn infants Am J Physiol Endocrinol Metab, March 1, 2002; 282(3): E618 - E625. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
