AJP - Endocrinology and Metabolism, Vol 268, Issue 4 E546-E550, Copyright © 1995 by American Physiological Society

ARTICLES

Dietary fat and adiposity: a dose-response relationship in adult male rats fed isocalorically

C. N. Boozer, G. Schoenbach and R. L. Atkinson
Medical Research Service, Department of Veterans Affairs Medical Center, Hampton 23667, USA.

This study examined the effects of increasing levels of dietary fat fed isocalorically on body weight, body composition, and adipose distribution. Adult male rats were weight matched into four groups. One group that was fed a low-fat diet (12%) served as reference controls. The other three groups were fed diets of 24, 36, or 48% fat in amounts to equal the energy intake of the control group. After 6 wk, body weights of the four groups were not significantly different. Intrascapular brown fat did not differ between groups. Total body fat and adipose depot weights, however, increased in proportion to the level of fat in the diet. Total body fat and retroperitoneal and mesenteric depot weights of the 48% fat group were greater than controls (P < 0.05). Mesenteric fat in this group was also significantly increased over all other groups (P < 0.05). These results show that high-fat diets fed to adult animals cause increased body fat in the absence of significant changes in body weight and that mesenteric fat is increased disproportionately.

This article has been cited by other articles:

				A. Mitra, K. M. Alvers, E. M. Crump, and N. E. Rowland Effect of high-fat diet during gestation, lactation, or postweaning on physiological and behavioral indexes in borderline hypertensive rats Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2009; 296(1): R20 - R28. [Abstract] [Full Text] [PDF]

				S. R. Commerford, M. J. Pagliassotti, C. L. Melby, Y. Wei, E. C. Gayles, and J. O. Hill Fat oxidation, lipolysis, and free fatty acid cycling in obesity-prone and obesity-resistant rats Am J Physiol Endocrinol Metab, October 1, 2000; 279(4): E875 - E885. [Abstract] [Full Text] [PDF]

				L.-M. Atkin and P. S. Davies Diet composition and body composition in preschool children Am. J. Clinical Nutrition, July 1, 2000; 72(1): 15 - 21. [Abstract] [Full Text] [PDF]

				M. Covasa and R. C. Ritter Reduced sensitivity to the satiation effect of intestinal oleate in rats adapted to high-fat diet Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1999; 277(1): R279 - R285. [Abstract] [Full Text] [PDF]

				P. J. Hope, I. Chapman, J. E. Morley, M. Horowitz, and G. A. Wittert Effect of diet on the response to leptin in the marsupial Sminthopsis crassicaudata Am J Physiol Regulatory Integrative Comp Physiol, February 1, 1999; 276(2): R373 - R381. [Abstract] [Full Text] [PDF]

				A. Carrillo, R. Rising, R. Tverskaya, and F. Lifshitz Effects of Exogenous Recombinant Human Growth Hormone on an Animal Model of Suboptimal Nutrition J. Am. Coll. Nutr., June 1, 1998; 17(3): 276 - 281. [Abstract] [Full Text] [PDF]

				J. Wang, J. T. Alexander, P. Zheng, H. J. Yu, J. Dourmashkin, and S. F. Leibowitz Behavioral and endocrine traits of obesity-prone and obesity-resistant rats on macronutrient diets Am J Physiol Endocrinol Metab, June 1, 1998; 274(6): E1057 - E1066. [Abstract] [Full Text] [PDF]

				S. F. Leibowitz, A. Akabayashi, and J. Wang Obesity on a High-Fat Diet: Role of Hypothalamic Galanin in Neurons of the Anterior Paraventricular Nucleus Projecting to the Median Eminence J. Neurosci., April 1, 1998; 18(7): 2709 - 2719. [Abstract] [Full Text] [PDF]

				L. L. Birch and J. O. Fisher Development of Eating Behaviors Among Children and Adolescents Pediatrics, March 1, 1998; 101(3): 539 - 549. [Abstract] [Full Text] [PDF]