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Am J Physiol Endocrinol Metab 268: E368-E374, 1995;
0193-1849/95 $5.00
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AJP - Endocrinology and Metabolism, Vol 268, Issue 2 E368-E374, Copyright © 1995 by American Physiological Society

ARTICLES

Effect of protein malnutrition on neutral amino acid transport by rat hepatocytes during development

M. Gomez-Angelats, B. Ruiz-Montasell, A. Felipe, J. J. Marin, F. J. Casado and M. Pastor-Anglada
Departament de Bioquimica i Fisiologia, Universitat de Barcelona, Spain.

Hepatocytes from suckling rats whose mothers were fed a low-protein diet (9% protein) showed a lower capacity for Na(+)-dependent L-alanine uptake [due to a decrease in maximal uptake rate (Vmax) of a low-affinity component of transport] and were not able to respond to insulin or glucagon, whereas those from suckling pups whose mothers were fed the control diet (17% protein) had already developed the ability to upregulate L-alanine transport after hormone treatment. When animals from low-protein-fed mothers were weaned onto a hypoprotein diet, the overall capacity for Na(+)-dependent L-alanine uptake (apparent Vmax) and its responsiveness to pancreatic hormones were restored. Hepatocytes from these animals showed a lower response to glucocorticoid treatment. Amino acid availability was dramatically decreased in suckling and weanling rats fed a low-protein diet. These results support the hypothesis that nutrient supply is an important factor in the proper development of hepatic transport functions during the suckling-weaning transition.


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