AJP - Endo Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 267: E853-E859, 1994;
0193-1849/94 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tobias, J. H.
Right arrow Articles by Chambers, T. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tobias, J. H.
Right arrow Articles by Chambers, T. J.

AJP - Endocrinology and Metabolism, Vol 267, Issue 6 E853-E859, Copyright © 1994 by American Physiological Society

ARTICLES

5 alpha-Dihydrotestosterone partially restores cancellous bone volume in osteopenic ovariectomized rats

J. H. Tobias, A. Gallagher and T. J. Chambers
Department of Histopathology, St. George's Hospital Medical School, London, United Kingdom.

Although androgens are thought to be important for skeletal maintenance in females and males, little is known about the mechanisms involved. To investigate this question further, we examined the effects of administering 0.01, 0.1, or 1.0 mg/kg 5 alpha-dihydrotestosterone (DHT) for 60 days on the skeleton of ovariectomized rats. Treatment was delayed until 90 days after ovariectomy to enable bone loss to stabilize. We found that ovariectomy markedly reduced cancellous bone volume of the proximal tibial metaphysis due to a combination of loss and thinning of trabeculae. Cancellous bone volume was partially restored by all doses of DHT, with trabecular thickness, but not number, returning to that of sham-operated animals. DHT also stimulated longitudinal bone growth and endosteal and periosteal bone formation and suppressed histomorphometric indexes of cancellous bone resorption. This suggests that DHT influences skeletal metabolism in osteopenic ovariectomized rats both by stimulating bone formation and suppressing resorption, although it is unclear which, if any, of these actions predominate at cancellous sites.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. F. Yarrow, C. F. Conover, A. V. Purandare, A. M. Bhakta, N. Zheng, B. Conrad, M. K. Altman, S. E. Franz, T. J. Wronski, and S. E. Borst
Supraphysiological testosterone enanthate administration prevents bone loss and augments bone strength in gonadectomized male and female rats
Am J Physiol Endocrinol Metab, November 1, 2008; 295(5): E1213 - E1222.
[Abstract] [Full Text] [PDF]

Home page
 Recent Prog Horm ResHome page
S.C. Manolagas, S. Kousteni, and R.L. Jilka
Sex Steroids and Bone
Recent Prog. Horm. Res., January 1, 2002; 57(1): 385 - 409.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
C. K. Lea and A. M. Flanagan
Physiological plasma levels of androgens reduce bone loss in the ovariectomized rat
Am J Physiol Endocrinol Metab, February 1, 1998; 274(2): E328 - E335.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online