AJP - Endocrinology and Metabolism, Vol 267, Issue 5 E775-E780, Copyright © 1994 by American Physiological Society

ARTICLES

Effects of glucose-to-lipid ratio and type of lipid on substrate oxidation rate in patients

B. Delafosse, J. P. Viale, S. Tissot, S. Normand, C. Pachiaudi, J. Goudable, Y. Bouffard, G. Annat and O. Bertrand
Intensive Care Unit, Hopital Edouard Herriot, Lyon, France.

This study is an investigation into the effects of different carbohydrate-to-lipid ratios on CO2 production in postoperative patients and the determination of the substrate oxidation rates induced by long-chain triglycerides (LCT) or a mixture of long- and medium-chain triglycerides (MCT/LCT) at various carbohydrate-to-lipid ratios. Two groups of eight patients randomly received either LCT or MCT/LCT emulsions. Total caloric intake was set at the measured energy expenditure provided at three different glucose-to-lipid ratios (70:30, 50:50, 30:70). We used long-term indirect calorimetry with a mass spectrometer system and measurement of natural enrichment in 13C of expired CO2 and plasma glucose. The carbon dioxide production and minute ventilation were not different among the different glucose-to-lipid ratios, whatever the type of lipid. Increasing the lipid supply up to 70% of nonprotein caloric intake led to an only minor increase in lipid oxidation rate and thus to a net fat deposit. We conclude that large amounts of lipid (LCT or MCT/LCT) were not of interest in such patients.

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