AJP - Endocrinology and Metabolism, Vol 266, Issue 6 E845-E851, Copyright © 1994 by American Physiological Society
Thermogenic, hormonal, and metabolic effects of a TPN mixture. Influence of glucose and amino acids
G. L. Carlson, P. Gray, J. Arnold, R. A. Little and M. H. Irving
Department of Surgery, Hope Hospital, Salford, United Kingdom.
The thermogenic, hormonal, and metabolic effects of intravenous nutrition
were examined by administering a complete total parenteral nutrition (TPN)
mixture to 11 subjects, and the relative contributions of the glucose and
amino acid components of the mixture were evaluated by administering these
nutrients separately (n = 7 and n = 6, respectively). The complete TPN
mixture caused a 22.9% rise in resting energy expenditure (REE), which
significantly exceeded that associated with glucose (10.4% P < 0.02).
The rise in REE produced by the amino acids (11.5%) did not differ
significantly from that associated with administration of the TPN or
glucose. The rise in REE associated with the TPN was almost exactly equal
to the sum of the rises associated with the separate components of the
mixture (22.9% and 22.0%, respectively), indicating that glucose and amino
acids contributed equally to the thermogenic effect of the TPN mixture. In
contrast, although the amino acid component of the TPN mixture was
associated with small but significant reductions in plasma free fatty acid
and glycerol concentration and with small increases in plasma insulin
concentration, the effects of the complete TPN mixture were significantly
greater and attributable to the glucose component.
