AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 266: E254-E260, 1994;
0193-1849/94 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Swoap, S. J.
Right arrow Articles by Baldwin, K. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Swoap, S. J.
Right arrow Articles by Baldwin, K. M.

AJP - Endocrinology and Metabolism, Vol 266, Issue 2 E254-E260, Copyright © 1994 by American Physiological Society

ARTICLES

Effect of chronic energy deprivation on cardiac thyroid hormone receptor and myosin isoform expression

S. J. Swoap, F. Haddad, P. Bodell and K. M. Baldwin
Department of Physiology and Biophysics, University of California, Irvine 92717.

Thyroid hormone (3,5,3'-triiodothyronine; T3) and its receptor (TR) play an important regulatory role for in vivo and in vitro cardiac myosin heavy chain (MHC) isoform gene expression by activating the alpha- and inhibiting the beta-MHC genes. Previous studies have shown that chronic energy deprivation (CED; 50% of normal caloric intake) in the rat impacts cardiac MHC protein expression and hemodynamic parameters in a pattern typically seen with hypothyroidism; yet, unlike hypothyroidism, circulating T3 levels are not depressed. Therefore, the goal of this study was to determine if the altered MHC isoform expression observed in CED is associated with altered TR expression, both at the mRNA and protein levels. Female rats weighing approximately 250 g were allocated into two groups, designated as normal control (NC) and CED. After 5 wk, the relative content of alpha-MHC protein and mRNA levels decreased in CED ventricles by 20% (P < 0.05). In contrast, the relative content of both beta-MHC protein and mRNA levels increased five- to sixfold in CED (P < 0.05). Although there were no changes in TR mRNA levels relative to 18S rRNA in CED, the total number of nuclear TRs decreased 3.5-fold in the CED group (P < 0.05), from a maximum binding capacity of 840 +/- 130 fmol/mg DNA in NC to 241 +/- 118 fmol/mg DNA in CED, with no change in the affinity of the receptor.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
C. A. Ray, M. Vasques, T. A. Miller, M. K. Wilkerson, and M. D. Delp
Effect of short-term microgravity and long-term hindlimb unloading on rat cardiac mass and function
J Appl Physiol, September 1, 2001; 91(3): 1207 - 1213.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
K. Kinugawa, W. A. Minobe, W. M. Wood, E. C. Ridgway, J. D. Baxter, R. C. J. Ribeiro, M. F. Tawadrous, B. A. Lowes, C. S. Long, and M. R. Bristow
Signaling Pathways Responsible for Fetal Gene Induction in the Failing Human Heart : Evidence for Altered Thyroid Hormone Receptor Gene Expression
Circulation, February 27, 2001; 103(8): 1089 - 1094.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. M. Baldwin and F. Haddad
Plasticity in Skeletal, Cardiac, and Smooth Muscle: Invited Review: Effects of different activity and inactivity paradigms on myosin heavy chain gene expression in striated muscle
J Appl Physiol, January 1, 2001; 90(1): 345 - 357.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. M. Giger, F. Haddad, A. X. Qin, and K. M. Baldwin
In vivo regulation of the beta -myosin heavy chain gene in soleus muscle of suspended and weight-bearing rats
Am J Physiol Cell Physiol, June 1, 2000; 278(6): C1153 - C1161.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. R. Adams, F. Haddad, S. A. McCue, P. W. Bodell, M. Zeng, L. Qin, A. X. Qin, and K. M. Baldwin
Effects of spaceflight and thyroid deficiency on rat hindlimb development. II. Expression of MHC isoforms
J Appl Physiol, March 1, 2000; 88(3): 904 - 916.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. R. Adams, F. Haddad, and K. M. Baldwin
Time course of changes in markers of myogenesis in overloaded rat skeletal muscles
J Appl Physiol, November 1, 1999; 87(5): 1705 - 1712.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
F. Haddad, A. X. Qin, S. A. McCue, and K. M. Baldwin
Thyroid receptor plasticity in striated muscle types: effects of altered thyroid state
Am J Physiol Endocrinol Metab, June 1, 1998; 274(6): E1018 - E1026.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. J. Swoap
In vivo analysis of the myosin heavy chain IIB promoter region
Am J Physiol Cell Physiol, March 1, 1998; 274(3): C681 - C687.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
H. L. Katzeff, S. R. Powell, and K. Ojamaa
Alterations in cardiac contractility and gene expression during low-T3 syndrome: prevention with T3
Am J Physiol Endocrinol Metab, November 1, 1997; 273(5): E951 - E956.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online