AJP - Endo Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 266: E129-E135, 1994;
0193-1849/94 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yeh, J. K.
Right arrow Articles by Millard, W. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yeh, J. K.
Right arrow Articles by Millard, W. J.

AJP - Endocrinology and Metabolism, Vol 266, Issue 1 E129-E135, Copyright © 1994 by American Physiological Society

ARTICLES

Effect of growth hormone administration and treadmill exercise on serum and skeletal IGF-I in rats

J. K. Yeh, J. F. Aloia, M. Chen, N. Ling, H. C. Koo and W. J. Millard
Department of Medicine, Winthrop-University Hospital, Mineola 11501.

Growth factors may be mediators of local and systemic factors that enhance bone formation. This study examined the effect of treadmill exercise and ovine growth hormone administration on levels of insulin-like growth factor I (IGF-I) in serum (ng/ml), long bone, and vertebrae and on bone formation rate. Forty female rats were divided into four groups: control; exercise (17 m/min, 1 h/day); growth hormone (0.05 mg.100 g-1.day-1); growth hormone plus exercise. After 9 wk of study, the serum levels of IGF-I were higher in the intervention groups than in the control group; however, the IGF-I concentration and the periosteal bone formation rate in the long bone were significantly higher only in the exercised rats. The IGF-I concentration and the cancellous bone formation rate in the vertebrae did not differ among the experimental groups. The vertebral and long bone formation rate were correlated with bone concentrations of IGF-I. Serum levels of IGF-I were also correlated with serum osteocalcin and the long bone formation but not with the vertebral bone formation. The association of bone formation with serum and bone IGF-I supports the suggestion that IGF-I is one of the growth factors that regulate bone formation, in particular as a mediator of the response of bone to exercise.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
L. Rosendal, H. Langberg, A. Flyvbjerg, J. Frystyk, H. Orskov, and M. Kjar
Physical capacity influences the response of insulin-like growth factor and its binding proteins to training
J Appl Physiol, November 1, 2002; 93(5): 1669 - 1675.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. K. Yeh, M.-M. Chen, and J. F. Aloia
Effects of estrogen and growth hormone on skeleton in the ovariectomized rat with hypophysectomy
Am J Physiol Endocrinol Metab, October 1, 1997; 273(4): E734 - E742.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Eliakim, M. Moromisato, D. Moromisato, J. A. Brasel, C. Roberts Jr., and D. M. Cooper
Increase in muscle IGF-I protein but not IGF-I mRNA after 5 days of endurance training in young rats
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1997; 273(4): R1557 - R1561.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online