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Am J Physiol Endocrinol Metab 265: E585-E591, 1993;
0193-1849/93 $5.00
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AJP - Endocrinology and Metabolism, Vol 265, Issue 4 E585-E591, Copyright © 1993 by American Physiological Society

ARTICLES

Importance of brain IL-1 type II receptors in fever and thermogenesis in the rat

G. Luheshi, S. J. Hopkins, R. A. Lefeuvre, M. J. Dascombe, P. Ghiara and N. J. Rothwell
Department of Physiological Sciences, University of Manchester, United Kingdom.

Interleukin-1 (IL-1) acts centrally to induce fever and thermogenesis in rodents. The central actions of IL-1 alpha and IL-1 beta apparently involve different mechanisms, and the effects of IL-1 beta are not consistent with interaction with a type I (IL-1RI) 80-kDa receptor. In the present study the involvement of the type II IL-1 receptor (IL-1RII) was tested in the rat by examining the effects of central injection of a monoclonal antibody (ALVA-42), which blocks the IL-1RII. Pretreatment of rats with ALVA-42 (6 micrograms icv) inhibited the thermogenic and pyrogenic responses to intracerebroventricular injection of 5 ng (but not 50 ng) of IL-1 beta in conscious rats but did not significantly modify responses to IL-1 alpha. ALVA-42 also failed to modify the responses to peripherally administered IL-1 beta (1 microgram) but significantly attenuated the pyrogenic and thermogenic responses to peripheral (125 micrograms) or central (1 microgram) injection of endotoxin. These data indicate that IL-1RII mediates the central effects of a low dose of IL-1 beta, but not IL-1 alpha, on fever and thermogenesis in the rat. They also imply that responses to endotoxin are due, at least in part, to the activation of IL-1RII by IL-1 beta released within the brain and that effects of peripherally injected IL-1 beta involve different mechanisms, probably associated with IL-1RI.


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Brain type I but not type II IL-1 receptors mediate the effects of IL-1beta on behavior in mice
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 1998; 274(3): R735 - R740.
[Abstract] [Full Text] [PDF]


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