AJP - Endocrinology and Metabolism, Vol 265, Issue 4 E565-E571, Copyright © 1993 by American Physiological Society

ARTICLES

Long-term effects on pancreatic function of feeding a HC formula to rats during the preweaning period

S. Vadlamudi, B. K. Hiremagalur, L. Tao, S. C. Kalhan, R. N. Kalaria, H. L. Kaung and M. S. Patel
Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106.

We have investigated pancreatic changes associated with hyperinsulinemia and an insulin secretory response to an oral glucose load in a new rat model for obesity. Male Sprague-Dawley pups were reared on a high-carbohydrate (HC) or high-fat (HF) formula by gastrostomy during the suckling period and were weaned onto a stock diet. These animals remained either nutritionally unchallenged or challenged with a high-sucrose diet during the postweaning period. The HC formula-fed animals showed increased insulin concentrations in the plasma and pancreas and also showed impaired insulin secretory response compared with mother-fed control or HF animals in adult life. Immunocytochemical and morphometric studies revealed that hyperinsulinemia in the HC animals during the preweaning period and also in adult life was associated with hypertrophy of beta-cells in the pancreas. The results show that consumption of a HC formula during the suckling period influences pancreatic islet morphology resulting in hyperinsulinemia which eventually leads to the development of obesity later in adult life.

This article has been cited by other articles:

				P. Mitrani, M. Srinivasan, C. Dodds, and M. S. Patel Autonomic involvement in the permanent metabolic programming of hyperinsulinemia in the high-carbohydrate rat model Am J Physiol Endocrinol Metab, May 1, 2007; 292(5): E1364 - E1377. [Abstract] [Full Text] [PDF]

				P. Mitrani, M. Srinivasan, C. Dodds, and M. S. Patel Role of the autonomic nervous system in the development of hyperinsulinemia by high-carbohydrate formula feeding to neonatal rats Am J Physiol Endocrinol Metab, April 1, 2007; 292(4): E1069 - E1078. [Abstract] [Full Text] [PDF]

				M. Srinivasan, R. Aalinkeel, F. Song, P. Mitrani, J. D. Pandya, B. Strutt, D. J. Hill, and M. S. Patel Maternal hyperinsulinemia predisposes rat fetuses for hyperinsulinemia, and adult-onset obesity and maternal mild food restriction reverses this phenotype Am J Physiol Endocrinol Metab, January 1, 2006; 290(1): E129 - E134. [Abstract] [Full Text] [PDF]

				M. Srinivasan, R. Aalinkeel, F. Song, and M. S. Patel Programming of Islet Functions in the Progeny of Hyperinsulinemic/Obese Rats Diabetes, April 1, 2003; 52(4): 984 - 990. [Abstract] [Full Text] [PDF]

				J.-W. Lee and D. R. Romsos Leptin Administration Normalizes Insulin Secretion from Islets of Lepob/Lepob Mice by Food Intake-Dependent and -Independent Mechanisms Experimental Biology and Medicine, February 1, 2003; 228(2): 183 - 187. [Abstract] [Full Text] [PDF]

				M. Srinivasan, S. G. Laychock, D. J. Hill, and M. S. Patel Neonatal Nutrition: Metabolic Programming of Pancreatic Islets and Obesity Experimental Biology and Medicine, January 1, 2003; 228(1): 15 - 23. [Abstract] [Full Text] [PDF]

				R. Aalinkeel, M. Srinivasan, F. Song, and M. S. Patel Programming into adulthood of islet adaptations induced by early nutritional intervention in the rat Am J Physiol Endocrinol Metab, September 1, 2001; 281(3): E640 - E648. [Abstract] [Full Text] [PDF]

				F. Song, M. Srinivasan, R. Aalinkeel, and M. S. Patel Use of a cDNA Array for the Identification of Genes Induced in Islets of Suckling Rats by a High-Carbohydrate Nutritional Intervention Diabetes, September 1, 2001; 50(9): 2053 - 2060. [Abstract] [Full Text] [PDF]

				M. Srinivasan, R. Aalinkeel, F. Song, B. Lee, S. G. Laychock, and M. S. Patel Adaptive changes in insulin secretion by islets from neonatal rats raised on a high-carbohydrate formula Am J Physiol Endocrinol Metab, December 1, 2000; 279(6): E1347 - E1357. [Abstract] [Full Text] [PDF]

				R. Aalinkeel, M. Srinivasan, S. C. Kalhan, S. G. Laychock, and M. S. Patel A dietary intervention (high carbohydrate) during the neonatal period causes islet dysfunction in rats Am J Physiol Endocrinol Metab, December 1, 1999; 277(6): E1061 - E1069. [Abstract] [Full Text] [PDF]

				R. A Waterland and C. Garza Potential mechanisms of metabolic imprinting that lead to chronic disease Am. J. Clinical Nutrition, February 1, 1999; 69(2): 179 - 197. [Abstract] [Full Text] [PDF]

				M. S. Patel and M. Srinivasan Metabolic Programming: Causes and Consequences J. Biol. Chem., January 11, 2002; 277(3): 1629 - 1632. [Full Text] [PDF]