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Am J Physiol Endocrinol Metab 264: E717-E722, 1993;
0193-1849/93 $5.00
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AJP - Endocrinology and Metabolism, Vol 264, Issue 5 E717-E722, Copyright © 1993 by American Physiological Society

ARTICLES

Acute fasting is ineffective in suppressing pituitary-gonadal function of pubertal male rats

M. Bergendahl and I. Huhtaniemi
Department of Physiology, University of Turku, Finland.

Effects of short-term fasting (3-4 days) on pituitary-testicular functions were studied during sexual maturation in male rats at 25, 35, 45, 55, and 65 days of age. Among the main findings, testicular testosterone decreased by 41-68% at all ages (P < 0.01-0.05). The pituitary steady-state mRNA levels of the common alpha-subunit (28-55%) and follicle-stimulating hormone (FSH) beta-subunit (25-50%) decreased (P < 0.01-0.05) at 25, 55, and 65 days of age but not at 35 and 45 days; the luteinizing hormone (LH) beta-subunit did not respond at any age. Fasting decreased serum LH (P < 0.01) at 25, 55, and 65 days of age but not at 35 and 45 days. Likewise, fasting decreased pituitary and/or serum FSH only in the 25- and 65-day-old rats (P < 0.01-0.05). In conclusion, LH and FSH secretion, and the gene expression of common alpha- and FSH beta-subunits, decreased consistently during short-term fasting only in prepubertal (25 days) and adult (65 days) but not in peripubertal animals (35 and 45 days). Hence, the pubertal rise in gonadotropins represents such a strong positive induction that it largely overrides the antigonadotropic effect of fasting.


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