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Am J Physiol Endocrinol Metab 264: E476-E481, 1993;
0193-1849/93 $5.00
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AJP - Endocrinology and Metabolism, Vol 264, Issue 3 E476-E481, Copyright © 1993 by American Physiological Society

ARTICLES

Remote and chronic access to the third cerebral ventricle of the unrestrained prepubertal rhesus monkey

V. L. Gay, N. Mikuma and T. M. Plant
Department of Physiology, University of Pittsburgh School of Medicine, Pennsylvania 15261.

One channel of a commercially available standard-size three-channel fluid swivel was modified to permit continuous access to the brain of unrestrained prepubertal rhesus monkeys via a continuous length of small-bore Teflon tube originating from a swivel device on top of the animal's cage and terminating in the third cerebral ventricle. This system was employed to achieve continuous access to the third cerebroventricle in four monkeys for periods of up to 12 mo. The value of the system for studies of the neurochemical control of hypothalamic-releasing factor secretion was established by monitoring adenohypophysial responses to neurotransmitter receptor agonists infused into the third ventricle. Specifically, repetitive infusions of morphine (30 micrograms/infusion) elicited a robust train of prolactin discharges, and third ventricular administration of N-methyl-DL-aspartic acid (NMA; 20 micrograms) resulted in striking discharges of LH.


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Neuropeptide Y: A hypothalamic brake restraining the onset of puberty in primates
PNAS, May 23, 2000; 97(11): 6179 - 6184.
[Abstract] [Full Text] [PDF]


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