AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 264: E264-E269, 1993;
0193-1849/93 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Carter, A. M.
Right arrow Articles by Challis, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Carter, A. M.
Right arrow Articles by Challis, J. R.

AJP - Endocrinology and Metabolism, Vol 264, Issue 2 E264-E269, Copyright © 1993 by American Physiological Society

ARTICLES

Regional adrenal blood flow responses to adrenocorticotropic hormone in fetal sheep

A. M. Carter, B. S. Richardson, J. Homan, M. Towstoless and J. R. Challis
Department of Obstetrics and Gynaecology, Lawson Research Institute, University of Western Ontario, London, Canada.

To determine whether adrenocorticotropic hormone (ACTH) at plasma concentrations measured during mild hypoxemia and at term affects adrenal blood flow, we measured regional blood flows in five unanesthetized normoxemic fetuses (125-130 days gestation) during a 24-h intravenous infusion of ACTH-(1-24) in isotonic saline solution. Another five fetuses received an infusion of vehicle. Blood flows were determined before the infusion, at 2 and 24 h from its onset, and 24 h afterward using radionuclide-labeled microspheres. Blood flow to the adrenal medulla was fivefold greater than that to the adrenal cortex. Adrenal blood flow rose 99% at 24 h of the ACTH infusion. There was a large increase in adrenal cortical blood flow of 272% at this time but medullary blood flow did not change significantly during ACTH infusion. The rise in cortical blood flow was attributable to decreased vascular resistance. No significant alterations occurred in fetal arterial blood pressure and heart rate, or in blood flow to other lower body organs of the fetus or to the placental cotyledons. These findings are consistent with the hypothesis that the increase in adrenal blood flow observed during fetal hypoxia is associated with changes in plasma ACTH concentration. They are also indicative of selective regulation of cortical and medullary blood flows in the sheep fetus at this stage of gestation.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
D. X. Zhang, K. M. Gauthier, and W. B. Campbell
Mechanisms of histamine-induced relaxation in bovine small adrenal cortical arteries
Am J Physiol Endocrinol Metab, December 1, 2005; 289(6): E1058 - E1063.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. F. Buchwalder, M. Lin, T. J. McDonald, and P. W. Nathanielsz
Fetal sheep adrenal blood flow responses to hypoxemia after splanchnicotomy using fluorescent microspheres
J Appl Physiol, January 1, 1998; 84(1): 82 - 89.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online