AJP - Endocrinology and Metabolism, Vol 264, Issue 1 E128-E135, Copyright © 1993 by American Physiological Society

ARTICLES

Estimation of protein fractional synthetic rate from tracer data

G. Toffolo, D. M. Foster and C. Cobelli
Department of Electronics and Informatics, University of Padua, Italy.

The fractional synthetic rate (FSR) is a key parameter characterizing protein turnover that is estimated from tracer kinetic data. Formulas to estimate this parameter usually assume a precursor-product model. Assuming this model is correct, we discuss these formulas to estimate the FSR in the steady and non-steady state both for the radioactive and stable isotope tracer. Then we deal with the non-steady-state case where the FSR becomes time varying and derive formulas for its estimation. A non-steady-state case study on the flooding-dose technique for measuring protein turnover is presented.

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