AJP - Endo AJP: Renal Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 262: E851-E855, 1992;
0193-1849/92 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Holmang, A.
Right arrow Articles by Bjorntorp, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Holmang, A.
Right arrow Articles by Bjorntorp, P.

AJP - Endocrinology and Metabolism, Vol 262, Issue 6 E851-E855, Copyright © 1992 by American Physiological Society

ARTICLES

Effects of short-term testosterone exposure on insulin sensitivity of muscles in female rats

A. Holmang, B. M. Larsson, Z. Brzezinska and P. Bjorntorp
Department of Medicine I, Sahlgrenska Hospital, University of Goteborg, Sweden.

The effects of testosterone on insulin sensitivity were studied in oophorectomized female rats. Euglycemic, hyperinsulinemic clamp measurement showed a marked decrease of insulin sensitivity after 48 but not 24 h of testosterone exposure, which was overcome at high insulin concentrations. Insulin stimulation of 2-deoxyglucose uptake as well as glycogen synthesis was measured in the white and red parts of the gastrocnemius, the extensor digitorum longus, and soleus muscles as well as in the liver (only glycogen synthesis). After 24 h of treatment, inhibition of both 2-deoxyglucose uptake and glycogen synthesis was found in the most insulin-sensitive muscles. After 48 h of insulin stimulation, glycogen synthesis was inhibited in all examined individual muscles (white and red parts of gastrocnemius, extensor digitorum longus, and soleus) as was the activity of the insulin-sensitive part of glycogen synthase in muscle. Inhibition of insulin-stimulated 2-deoxyglucose uptake again affected the most insulin-sensitive muscles. There was a slight but significant change of muscle fiber composition toward less long-chain myosin and more short-chain myosin-containing fibers. Serum cortisol, plasma free fatty acids, and blood glycerol did not change. It is concluded that testosterone administration in moderate doses to oophorectomized female rats is followed by a rapid deterioration of insulin sensitivity in muscle, mediated mainly by perturbations of the insulin receptor-glycogen synthesis systems apparently coinciding with changes in muscle morphology.


This article has been cited by other articles:


Home page
 Diabetes CareHome page
J.-Y. Oh, E. Barrett-Connor, N. M. Wedick, and D. L. Wingard
Endogenous Sex Hormones and the Development of Type 2 Diabetes in Older Men and Women: the Rancho Bernardo Study
Diabetes Care, January 1, 2002; 25(1): 55 - 60.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Niklasson, P. Daneryd, P. Lonnroth, and A. Holmang
Effects of exercise on insulin distribution and action in testosterone-treated oophorectomized female rats
J Appl Physiol, June 1, 2000; 88(6): 2116 - 2122.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A. Cagnacci, A.M. Paoletti, S. Arangino, G.B. Melis, and A. Volpe
Effect of ovarian suppression on glucose metabolism of young lean women with and without ovarian hyperandrogenism
Hum. Reprod., April 1, 1999; 14(4): 893 - 897.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online