AJP - Endocrinology and Metabolism, Vol 262, Issue 3 E253-E260, Copyright © 1992 by American Physiological Society

ARTICLES

Uncomplicated surgery, but not general anesthesia, decreases muscle protein synthesis

P. Essen, M. A. McNurlan, J. Wernerman, E. Vinnars and P. J. Garlick
Department of Anesthesiology, Huddinge University Hospital, Sweden.

The impact of anesthesia and surgery on protein metabolism is not well characterized. The single effect of general anesthesia and the combined effects of surgery and general anesthesia on protein synthesis in skeletal muscle were studied in metabolically healthy patients (n = 14) undergoing elective abdominal surgery. The rate of muscle protein synthesis was calculated from the increase in enrichment of [1-13C]leucine in protein during 90 min after an intravenous infusion of [1-13C]leucine (0.05 g/kg, 20 atom percent excess). The 1-13C enrichments of plasma leucine and plasma alpha-ketoisocaproate were used to indicate the enrichment of muscle free leucine. The protein synthesis rate was unaffected by general anesthesia; however, at the end of surgery, a 31.5% decline was seen from 2.19(2.13,2.33)%/24 h before anesthesia to 1.50(1.21,1.77)%/24 h (P less than 0.05) immediately after cholecystectomy while the patients were still under general anesthesia.

This article has been cited by other articles:

				A. Battezzati, A. Caumo, A. Fattorini, L. P. Sereni, J. Coppa, R. Romito, M. Ammatuna, E. Regalia, V. Mazzaferro, and L. Luzi Amino Acid Kinetics During the Anhepatic Phase of Liver Transplantation Diabetes, June 1, 2002; 51(6): 1690 - 1698. [Abstract] [Full Text] [PDF]

				T. Schricker, R. Lattermann, P. Fiset, L. Wykes, and F. Carli Integrated analysis of protein and glucose metabolism during surgery: effects of anesthesia J Appl Physiol, December 1, 2001; 91(6): 2523 - 2530. [Abstract] [Full Text] [PDF]

				H. Barle, B. Nyberg, S. Ramel, P. Essen, M. A. McNurlan, J. Wernerman, and P. J. Garlick Inhibition of liver protein synthesis during laparoscopic surgery Am J Physiol Endocrinol Metab, October 1, 1999; 277(4): E591 - E596. [Abstract] [Full Text] [PDF]

				H. Barle, P. Essen, B. Nyberg, H. Olivecrona, M. Tally, M. A. McNurlan, J. Wernerman, and P. J. Garlick Depression of liver protein synthesis during surgery is prevented by growth hormone Am J Physiol Endocrinol Metab, April 1, 1999; 276(4): E620 - E627. [Abstract] [Full Text] [PDF]

				N. C. Jackson, P. V. Carroll, D. L. Russell-Jones, P. H. Sonksen, D. F. Treacher, and A. M. Umpleby The metabolic consequences of critical illness: acute effects on glutamine and protein metabolism Am J Physiol Endocrinol Metab, January 1, 1999; 276(1): E163 - E170. [Abstract] [Full Text] [PDF]

				J.-L. Luo, F. Hammarqvist, K. Andersson, and J. Wernerman Surgical trauma decreases glutathione synthetic capacity in human skeletal muscle tissue Am J Physiol Endocrinol Metab, August 1, 1998; 275(2): E359 - E365. [Abstract] [Full Text] [PDF]

				O. Mansoor, M. Cayol, P. Gachon, Y. Boirie, P. Schoeffler, C. Obled, and B. Beaufrere Albumin and fibrinogen syntheses increase while muscle protein synthesis decreases in head-injured patients Am J Physiol Endocrinol Metab, November 1, 1997; 273(5): E898 - E902. [Abstract] [Full Text] [PDF]

				G. Caso, G. C. Ford, K. S. Nair, P. J. Garlick, and M. A. McNurlan Aminoacyl-tRNA enrichment after a flood of labeled phenylalanine: insulin effect on muscle protein synthesis Am J Physiol Endocrinol Metab, May 1, 2002; 282(5): E1029 - E1038. [Abstract] [Full Text] [PDF]