AJP - Endo Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 261: E500-E504, 1991;
0193-1849/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Peters, E. J.
Right arrow Articles by Wolfe, R. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Peters, E. J.
Right arrow Articles by Wolfe, R. R.

AJP - Endocrinology and Metabolism, Vol 261, Issue 4 E500-E504, Copyright © 1991 by American Physiological Society

ARTICLES

Effect of short-term fasting on the lipolytic response to theophylline

E. J. Peters, S. Klein and R. R. Wolfe
Metabolism Unit, Shriners Burns Institute, Galveston, Texas.

We investigated the hypothesis that the increase in lipolysis that occurs in short-term (86-h) fasting is due to a decreased inhibitory influence of adenosine. In normal volunteers who fasted for 14 and 86 h, the response to adenosine receptor blockade was assessed by the infusion of theophylline at a rate sufficient to produce plasma concentrations (30 microM) that blocked adenosine receptors but that were well below the threshold for inhibition of phosphodiesterase. Lipolysis was assessed by determining the rate of appearance of glycerol using D-5-glycerol infusion. Fatty acid flux was also determined by means of [1-13C]palmitate infusion, and total fatty acid oxidation was determined by indirect calorimetry. There was a mild stimulatory effect of theophylline on lipolysis at 14 h. After the subjects fasted for 86 h, theophylline infusion caused a much greater increase in both lipolysis and fatty acid oxidation. These results suggest that the inhibitory effect of adenosine on lipolysis is increased during short-term fasting.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
F. Greer, D. Friars, and T. E. Graham
Comparison of caffeine and theophylline ingestion: exercise metabolism and endurance
J Appl Physiol, November 1, 2000; 89(5): 1837 - 1844.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
V. P Carnielli, G. Verlato, F. Benini, K. Rossi, M. Cavedagni, M. Filippone, E. Baraldi, and F. Zacchello
Metabolic and respiratory effects of theophylline in the preterm infant
Arch. Dis. Child. Fetal Neonatal Ed., July 1, 2000; 83(1): 39F - 43.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
J. A. Romijn, E. F. Coyle, L. S. Sidossis, J. Rosenblatt, and R. R. Wolfe
Substrate metabolism during different exercise intensities in endurance-trained women
J Appl Physiol, May 1, 2000; 88(5): 1707 - 1714.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. B. Carey
Cellular adaptations in fat tissue of exercise-trained miniature swine: role of excess energy intake
J Appl Physiol, March 1, 2000; 88(3): 881 - 887.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online