AJP - Endo AJP: Gastrointestinal and Liver Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 261: E31-E40, 1991;
0193-1849/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Holst, J. J.
Right arrow Articles by Harling, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Holst, J. J.
Right arrow Articles by Harling, H.

AJP - Endocrinology and Metabolism, Vol 261, Issue 1 E31-E40, Copyright © 1991 by American Physiological Society

ARTICLES

Release of galanin from isolated perfused porcine adrenal glands: role of splanchnic nerves

J. J. Holst, M. Ehrhart-Bornstein, T. Messell, S. S. Poulsen and H. Harling
Institute of Medical Physiology C, Panum Institute, Copenhagen, Denmark.

We found a high concentration of galanin in extracts of porcine adrenal glands (114 pmol/g). By immunohistochemistry, galanin was localized to groups of medullary cells previously shown to produce norepinephrine. To study mechanisms for the release of galanin, we developed the following in vitro model: isolated perfused porcine adrenals with intact splanchnic nerve supply. When the nerves were electrically stimulated, epinephrine and norepinephrine secretion increased 276- and 291-fold, respectively, and galanin release increased up to 1,300-fold. Acetylcholine at 10(-6) M stimulated galanin release, and hexamethonium almost abolished the response to nerve stimulation. Galanin infusions had no effect on epinephrine and norepinephrine secretion in concentrations of 10(-8) and 10(-7) M, but increased both cortisol and aldosterone secretion (P less than 0.05). Splanchnic nerve stimulation in anesthetized pigs increased the concentration of galanin in the caval vein but not in arterial plasma. It is concluded that galanin, coreleased with catecholamines from the adrenal glands, may have endocrine functions but that galanin may also have local regulatory functions in the adrenals.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
K. Tornoe, J. Hannibal, T. B. Jensen, B. Georg, L. F. Rickelt, M. B. Andreasen, J. Fahrenkrug, and J. J. Holst
PACAP-(1-38) as neurotransmitter in the porcine adrenal glands
Am J Physiol Endocrinol Metab, December 1, 2000; 279(6): E1413 - E1425.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M.-L. Wong, M. A. Kling, P. J. Munson, S. Listwak, J. Licinio, P. Prolo, B. Karp, I. E. McCutcheon, T. D. Geracioti Jr., M. D. DeBellis, et al.
Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: Relation to hypercortisolism and corticotropin-releasing hormone
PNAS, January 4, 2000; 97(1): 325 - 330.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online