AJP - Endo Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 260: E876-E882, 1991;
0193-1849/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lenz, T.
Right arrow Articles by Sealey, J. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lenz, T.
Right arrow Articles by Sealey, J. E.

AJP - Endocrinology and Metabolism, Vol 260, Issue 6 E876-E882, Copyright © 1991 by American Physiological Society

ARTICLES

Prorenin secretion from human placenta perfused in vitro

T. Lenz, G. D. James, J. H. Laragh and J. E. Sealey
Cardiovascular Center, New York Hospital, Cornell University Medical College, New York 10021.

We examined whether renin (prorenin plus renin) is secreted from the human placenta into the maternal or fetal circulation and compared the secretion rate to that of human chorionic gonadotropin (hCG), progesterone, and estradiol. While estradiol and progesterone passed into both circulations, renin (mostly prorenin) and hCG were secreted predominantly into the maternal circulation. To examine if prorenin passed from the maternal to the fetal circulation and vice versa, we perfused both circuits separately with exogenous recombinant human prorenin. No prorenin passed from maternal to fetal circulations, but a small amount (less than 10%) slowly passed from fetal to maternal, beginning 15 min after the addition of prorenin. Exogenous prorenin was not converted to renin in either circulation. Perfusate total renin had close to 10% active renin, whereas that of tissue extracts was closer to 50%. In conclusion, the results are consistent with some tissue activation of prorenin, either in vitro or in vivo, but no activation in the maternal or fetal circulations. The human placenta may secrete prorenin into the maternal but not into the fetal circulation. The possibility that the placenta may secrete a small amount of active renin into the maternal circulation was not ruled out.


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
M. Paul, A. Poyan Mehr, and R. Kreutz
Physiology of local Renin-Angiotensin systems.
Physiol Rev, July 1, 2006; 86(3): 747 - 803.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
Y. Xia, H. Wen, H. R. Prashner, R. Chen, T. Inagami, D. F. Catanzaro, and R. E. Kellems
Pregnancy-Induced Changes in Renin Gene Expression in Mice
Biol Reprod, January 1, 2002; 66(1): 135 - 143.
[Abstract] [Full Text]

Home page
 HypertensionHome page
C. Li, R. Ansari, Z. Yu, and D. Shah
Definitive Molecular Evidence of Renin-Angiotensin System in Human Uterine Decidual Cells
Hypertension, August 1, 2000; 36(2): 159 - 164.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
C. Mercure, I. Jutras, R. Day, N. G. Seidah, and T. L. Reudelhuber
Prohormone Convertase PC5 Is a Candidate Processing Enzyme for Prorenin in the Human Adrenal Cortex
Hypertension, November 1, 1996; 28(5): 840 - 846.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online