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Am J Physiol Endocrinol Metab 260: E588-E593, 1991;
0193-1849/91 $5.00
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AJP - Endocrinology and Metabolism, Vol 260, Issue 4 E588-E593, Copyright © 1991 by American Physiological Society

ARTICLES

Nutritional regulation of glucose transporter in muscle and adipose tissue of weaned rats

A. Leturque, C. Postic, P. Ferre and J. Girard
Centre de Recherche sur la Nutrition, Centre National de la Recherche Scientifique, Meudon-Bellevue, France.

The role of glucose transporters GLUT-1 and GLUT-4 in the development of insulin sensitivity at weaning in rat skeletal muscles and adipose tissue was studied in relation to the nutritional changes when suckling rats shift from a high-fat (HF) to a high-carbohydrate (HCHO) diet. Insulin stimulated the translocation of GLUT-4 protein from an intracellular pool to the plasma membrane in adipocytes from suckling and HCHO- or HF-weaned rats. The GLUT-4 protein and the insulin stimulation were threefold higher in adipocytes from HCHO-weaned rats than in suckling or HF-weaned rats. GLUT-4 mRNA and protein were low in adipose tissue and skeletal muscles of suckling rats and increased two- to threefold in HCHO-weaned rats. This increase was prevented in HF-weaned rats. GLUT-1 mRNA was not affected in both tissues by the developmental stage or the nutritional environment. After feeding HCHO to a suckling rat, GLUT-4 mRNA was threefold increased in 6 days and reached a peak after 4 days in both tissues. The insulin sensitivity of glucose transport in rats at weaning might be conferred by an enhanced expression of GLUT-4, which can be induced within a few hours after feeding a HCHO diet.


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