| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Endocrinology and Metabolism, Vol 260, Issue 1 E101-E110, Copyright © 1991 by American Physiological Society
ARTICLES |
M. L. Hartman, A. C. Faria, M. L. Vance, M. L. Johnson, M. O. Thorner and J. D. Veldhuis
Department of Medicine, University of Virginia Health Sciences Center, Charlottesville 22908.
The time course of spontaneous growth hormone (GH) secretion was studied in 12 normal men by analyzing serum GH concentrations measured in blood collected at 5-min intervals over 24 h with a multiple-parameter deconvolution model to simultaneously resolve endogenous GH secretory and clearance rates. Twenty-four-hour profiles of serum GH concentrations were accounted for by an average of 12 +/- 1.2 (SE) discrete GH secretory bursts having a mean half-duration (duration at half-maximal amplitude) of 25 +/- 2.3 min, indicating that 95% of daily GH secretion occurred in 8.8 h. The majority (96%) of GH was secreted in volleys composed of multiple (4.0 +/- 0.4) discrete secretory bursts. Such volleys of GH secretion were separated by 171 +/- 19 min, whereas their constituent individual secretory events occurred every 36 +/- 1.7 min (P = 0.0001). Between secretory volleys, calculated GH secretory rates fell asymptotically to zero. Significant positive and negative autocorrelations were observed for the series consisting of successive GH secretory burst mass and interburst intervals, respectively. Linear regression analysis revealed significant negative correlations between the mass of GH secreted per burst and both the preceding and following interburst intervals. Estimates of the half-life of endogenous GH (17 +/- 1.7 min) and of the endogenous GH production rate (0.25 +/- 0.033 mg/m2 for an assumed distribution volume of 7.9% body wt) agreed well with earlier independent measurements. We conclude that the human pituitary gland secretes GH in volleys consisting of multiple secretory bursts, without measurable intervening tonic secretion. This pattern of in vivo GH release in normal humans is consistent with a model of high-frequency GH-releasing hormone secretory events superimposed on low-frequency episodes of somatostatin withdrawal.
This article has been cited by other articles:
|
|
 |
|
  E. de Graaf-Roelfsema, P. P. Veldhuis, H. A. Keizer, M. M. E. van Ginneken, K. G. van Dam, M. L. Johnson, A. Barneveld, P. P. C. A. Menheere, E. van Breda, I. D. Wijnberg, et al. Overtrained horses alter their resting pulsatile growth hormone secretion Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2009; 297(2): R403 - R411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Veldhuis, D. M. Keenan, and C. Y. Bowers Peripheral estrogen receptor-{alpha} selectively modulates the waveform of GH secretory bursts in healthy women Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2007; 293(4): R1514 - R1521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Farhy, C. Y. Bowers, and J. D. Veldhuis Model-projected mechanistic bases for sex differences in growth hormone regulation in humans Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2007; 292(4): R1577 - R1593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Farhy and J. D. Veldhuis Putative GH pulse renewal: periventricular somatostatinergic control of an arcuate-nuclear somatostatin and GH-releasing hormone oscillator Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2004; 286(6): R1030 - R1042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Farhy and J. D. Veldhuis Joint pituitary-hypothalamic and intrahypothalamic autofeedback construct of pulsatile growth hormone secretion Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2003; 285(5): R1240 - R1249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Farhy, M. Straume, M. L. Johnson, B. Kovatchev, and J. D. Veldhuis Unequal autonegative feedback by GH models the sexual dimorphism in GH secretory dynamics Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2002; 282(3): R753 - R764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Veldhuis, M. L. Johnson, O. L. Veldhuis, M. Straume, and S. M. Pincus Impact of pulsatility on the ensemble orderliness (approximate entropy) of neurohormone secretion Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2001; 281(6): R1975 - R1985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Farhy, M. Straume, M. L. Johnson, B. Kovatchev, and J. D. Veldhuis A construct of interactive feedback control of the GH axis in the male Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2001; 281(1): R38 - R51. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. V. Dimaraki, C. A. Jaffe, R. Demott-Friberg, M. Russell-Aulet, C. Y. Bowers, P. Marbach, and A. L. Barkan Generation of growth hormone pulsatility in women: evidence against somatostatin withdrawal as pulse initiator Am J Physiol Endocrinol Metab, March 1, 2001; 280(3): E489 - E495. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. D. McMahon, L. T. Chapin, K. J. Lookingland, R. P. Radcliff, and H. A. Tucker Feeding Reduces Activity of Growth Hormone-Releasing Hormone and Somatostatin Neurons Experimental Biology and Medicine, February 1, 2000; 223(2): 210 - 217. [Abstract] [Full Text]
|
|
|
|
|
|
C. H. Gravholt, O. Schmitz, L. Simonsen, J. Bulow, J. S. Christiansen, and N. Moller Effects of a physiological GH pulse on interstitial glycerol in abdominal and femoral adipose tissue Am J Physiol Endocrinol Metab, November 1, 1999; 277(5): E848 - E854. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Shah, W. S. Evans, and J. D. Veldhuis Actions of estrogen on pulsatile, nyctohemeral, and entropic modes of growth hormone secretion Am J Physiol Regulatory Integrative Comp Physiol, May 1, 1999; 276(5): R1351 - R1358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. E. Muller, V. Locatelli, and D. Cocchi Neuroendocrine Control of Growth Hormone Secretion Physiol Rev, April 1, 1999; 79(2): 511 - 607. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Cappellin, R. Gatti, and E. F. De Palo Influence of Gender in Growth Hormone Status in Adults: Role of Urinary Growth Hormone Clin. Chem., March 1, 1999; 45(3): 443 - 444. [Full Text] [PDF]
|
|
|
|
|
|
H. G. Maheshwari, S. S. Pezzoli, A. Rahim, S. M. Shalet, M. O. Thorner, and G. Baumann Pulsatile growth hormone secretion persists in genetic growth hormone-releasing hormone resistance Am J Physiol Endocrinol Metab, April 1, 2002; 282(4): E943 - E951. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
