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Am J Physiol Endocrinol Metab 259: E844-E850, 1990;
0193-1849/90 $5.00
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AJP - Endocrinology and Metabolism, Vol 259, Issue 6 E844-E850, Copyright © 1990 by American Physiological Society

ARTICLES

Characterization of the process of sodium-calcium exchange in pancreatic islet cells

P. O. Plasman, P. Lebrun and A. Herchuelz
Laboratory of Pharmacology, Brussels University, School of Medicine, Belgium.

Na(+)-Ca2+ exchange may play a role in Ca2+ extrusion from the pancreatic B-cell. The characteristics of the process working in its reverse mode were examined in normal rat pancreatic islet cells. Isosmotical replacement of extracellular Na+ by sucrose induced a concentration-dependent increase in 45Ca uptake, displaying a pharmacological sensitivity compatible with an uptake mediated by Na(+)-Ca2+ exchange. Glucose, up to 2.8 mM, stimulated reverse Na(+)-Ca2+ exchange. Likewise, membrane depolarization activated the process but only under raised intracellular Na+ activity. In conclusion, the B-cell Na(+)-Ca2+ exchange displays properties similar to those observed in other cells: reversibility and sensitivity to membrane potential. When working in its reverse mode the exchanger displays a quite large capacity. The role played by the exchanger in the process of insulin release warrants further investigation.


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