AJP - Endo Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 259: E763-E769, 1990;
0193-1849/90 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (43)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wusteman, M.
Right arrow Articles by Elia, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wusteman, M.
Right arrow Articles by Elia, M.

AJP - Endocrinology and Metabolism, Vol 259, Issue 6 E763-E769, Copyright © 1990 by American Physiological Society

ARTICLES

Protein metabolism after injury with turpentine: a rat model for clinical trauma

M. Wusteman, D. G. Wight and M. Elia
Medical Research Council Dunn Nutrition Unit, Cambridge, United Kingdom.

Subcutaneous injections of turpentine induced discrete aseptic abscesses in rats without detectable injury to other tissues. Hypoalbuminemia and high circulating concentrations of alpha 2-macroglobulin were present after 48 h. Liver size, protein content, and protein fractional synthetic rate (FSR) were all increased, whereas loss of muscle protein occurred together with similar (45-50%) reductions in both intramuscular glutamine concentrations ([Gln]i, mmol/l intracellular water) and FSR. The rats became anorexic, but pair feeding (50% ad libitum for 48 h) produced a 22% increase in muscle [Gln]i and only an 18% reduction in muscle FSR. Dietary restriction therefore did not demonstrate the positive relationship between muscle [Gln]i and FSR, which has been observed in animal trauma studies. It is concluded that subcutaneous injections of turpentine produce many of the features of the acute-phase response to injury, and therefore this technique is recommended as a convenient laboratory model for studying various aspects of the protein metabolic response to injury.


This article has been cited by other articles:


Home page
 J. Physiol.Home page
A. Aguilar-Valles, S. Poole, Y. Mistry, S. Williams, and G. N. Luheshi
Attenuated fever in rats during late pregnancy is linked to suppressed interleukin-6 production after localized inflammation with turpentine
J. Physiol., August 15, 2007; 583(1): 391 - 403.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
S. Mercier, D. Breuille, L. Mosoni, C. Obled, and P. Patureau Mirand
Chronic Inflammation Alters Protein Metabolism in Several Organs of Adult Rats
J. Nutr., July 1, 2002; 132(7): 1921 - 1928.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Valles, O. Marti, A. Garcia, and A. Armario
Single exposure to stressors causes long-lasting, stress-dependent reduction of food intake in rats
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2000; 279(3): R1138 - R1144.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
A. V. Kurpad, F. Jahoor, S. Borgonha, S. Poulo, S. Rekha, C. R. Fjeld, and P. J. Reeds
A Minimally Invasive Tracer Protocol Is Effective for Assessing the Response of Leucine Kinetics and Oxidation to Vaccination in Chronically Energy-Deficient Adult Males and Children
J. Nutr., August 1, 1999; 129(8): 1537 - 1544.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online