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Am J Physiol Endocrinol Metab 259: E763-E769, 1990;
0193-1849/90 $5.00
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AJP - Endocrinology and Metabolism, Vol 259, Issue 6 E763-E769, Copyright © 1990 by American Physiological Society

ARTICLES

Protein metabolism after injury with turpentine: a rat model for clinical trauma

M. Wusteman, D. G. Wight and M. Elia
Medical Research Council Dunn Nutrition Unit, Cambridge, United Kingdom.

Subcutaneous injections of turpentine induced discrete aseptic abscesses in rats without detectable injury to other tissues. Hypoalbuminemia and high circulating concentrations of alpha 2-macroglobulin were present after 48 h. Liver size, protein content, and protein fractional synthetic rate (FSR) were all increased, whereas loss of muscle protein occurred together with similar (45-50%) reductions in both intramuscular glutamine concentrations ([Gln]i, mmol/l intracellular water) and FSR. The rats became anorexic, but pair feeding (50% ad libitum for 48 h) produced a 22% increase in muscle [Gln]i and only an 18% reduction in muscle FSR. Dietary restriction therefore did not demonstrate the positive relationship between muscle [Gln]i and FSR, which has been observed in animal trauma studies. It is concluded that subcutaneous injections of turpentine produce many of the features of the acute-phase response to injury, and therefore this technique is recommended as a convenient laboratory model for studying various aspects of the protein metabolic response to injury.


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