AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 259: E256-E260, 1990;
0193-1849/90 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brown, P. I.
Right arrow Articles by Fisher, D. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brown, P. I.
Right arrow Articles by Fisher, D. A.

AJP - Endocrinology and Metabolism, Vol 259, Issue 2 E256-E260, Copyright © 1990 by American Physiological Society

ARTICLES

Transforming growth factor alpha in developing rats

P. I. Brown, R. Lam, J. Lakshmanan and D. A. Fisher
Department of Pediatrics, Harbor-University of California, UCLA School of Medicine, Torrance.

Transforming growth factor-alpha (TGF-alpha) concentrations were measured in lung, brain, liver, and kidney of rats at three different ages (20 days gestation and 9 and 50 days postnatal). TGF-alpha concentrations were maximal in the lung and brain by 20 days of gestation and showed minimal changes during nursing (day 9) and young adulthood (day 50). The liver, which also showed maximal TGF-alpha concentration by 20 days of gestation, demonstrated a progressive reduction with age to nadir values in the young adult. In contrast to the pattern in other tissues, kidney had the lowest concentration of TGF-alpha in late gestation and showed an increase by 50 days of age. As TGF-alpha acts via the epidermal growth factor (EGF) receptor, its function in development may be analogous to that of EGF. Thus TGF-alpha may have a role in lung maturation and postinjury repair, liver repair and regeneration, and neuronal cell growth.


This article has been cited by other articles:


Home page
 Am. J. Pathol.Home page
T. Tomiya, I. Ogata, and K. Fujiwara
Transforming Growth Factor {alpha} Levels in Liver and Blood Correlate Better than Hepatocyte Growth Factor with Hepatocyte Proliferation during Liver Regeneration
Am. J. Pathol., September 1, 1998; 153(3): 955 - 961.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
B Egger, H V Carey, F Procaccino, N-N Chai, E P Sandgren, J Lakshmanan, V S Buslon, S W French, M W Buchler, and V E Eysselein
Reduced susceptibility of mice overexpressing transforming growth factor alpha  to dextran sodium sulphate induced colitis
Gut, July 1, 1998; 43(1): 64 - 70.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online