AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 259: E11-E18, 1990;
0193-1849/90 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kaul, R.
Right arrow Articles by Schmidt, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kaul, R.
Right arrow Articles by Schmidt, I.

AJP - Endocrinology and Metabolism, Vol 259, Issue 1 E11-E18, Copyright © 1990 by American Physiological Society

ARTICLES

Defective thermoregulatory thermogenesis does not cause onset of obesity in Zucker rats

R. Kaul, G. Heldmaier and I. Schmidt
W. G. Kerckhoff Institut, Max-Planck Institut fur Physiologische und klinische Forschung, Bad Nauheim, Federal Republic of Germany.

To test whether or not the onset of obesity in fatty (fa/fa) Zucker rats is caused by decreased thermoregulatory thermogenesis, pups were artificially reared above their lower critical temperature from 3 or 4 days of age. Littermates were continuously fed identical amounts of synthetic rat milk while body temperature (Tc) and oxygen consumption rate (VO2) were continuously recorded. When the daily mean Tc of all pups was held greater than 37 degrees C, neither Tc nor VO2 differed between fa/fa and genetically lean (Fa/-) pups during the first 2 wk of life. Tc and VO2 were significantly elevated in Fa/- pups during the third postnatal week. At both 16 and 21 days of age, fa/fa pups were identified by their low Tc during a brief cold exposure. Body fat and fat-free dry mass of fa/fa and Fa/- littermates differed at 21 but not at 16 days of age. The excess energy deposited as fat was partly derived from decreased nonthermoregulatory energy expenditure and decreased synthesis of lean body mass. Calculations support the speculation that a greater extraction of energy from the synthetic diet additionally supports the excess fat deposition. Decreased thermoregulatory thermogenesis and excess fat storage appear to be secondary and independent consequences of the primary genetic lesion.


This article has been cited by other articles:


Home page
 Physiol. GenomicsHome page
K. Weide, N. Christ, K. M. Moar, J. Arens, A. Hinney, J. G. Mercer, S. Eiden, and I. Schmidt
Hyperphagia, not hypometabolism, causes early onset obesity in melanocortin-4 receptor knockout mice
Physiol Genomics, March 18, 2003; 13(1): 47 - 56.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
Y. ZHANG, C. HUFNAGEL, S. EIDEN, K.-Y. GUO, P. A. DIAZ, R. L. LEIBEL, and I. SCHMIDT
Mechanisms for LEPR-mediated regulation of leptin expression in brown and white adipocytes in rat pups
Physiol Genomics, January 19, 2001; 4(3): 189 - 199.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
I. SCHMIDT, C. SCHOELCH, T. ZISKA, D. SCHNEIDER, E. SIMON, and A. PLAGEMANN
Interaction of genetic and environmental programming of the leptin system and of obesity disposition
Physiol Genomics, August 9, 2000; 3(2): 113 - 120.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online