| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Endocrinology and Metabolism, Vol 258, Issue 6 E923-E929, Copyright © 1990 by American Physiological Society
ARTICLES |
D. E. Kelley, J. P. Reilly, T. Veneman and L. J. Mandarino
Department of Medicine, University of Pittsburgh School of Medicine, Presbyterian-University Hospital, Pennsylvania 15213.
The effects of physiological hyperinsulinemia (approximately 75 mU/l) on glucose storage, oxidation, and glycolysis in skeletal muscle were assessed with euglycemic clamps performed in seven healthy volunteers, in conjunction with leg balance for glucose, lactate, alanine, O2, and CO2. Infusion of insulin increased leg glucose uptake, storage, and oxidation but did not alter net release of lactate and alanine. The respiratory quotient (RQ) across the leg increased from a basal value of 0.74 +/- 0.02 to 0.99 +/- 0.02 during hyperinsulinemia. Under conditions of insulin stimulation, 49 +/- 5% of leg glucose uptake was stored, 37 +/- 4% was oxidized, and 14 +/- 2% was released as lactate and alanine. We conclude that during physiological hyperinsulinemia and euglycemia 1) skeletal muscle lipid oxidation is nearly entirely suppressed and glucose becomes the primary oxidative substrate of muscle, 2) glucose storage and oxidation are the major pathways of skeletal muscle glucose metabolism and are quantitatively similar at physiological insulin levels, and 3) the majority of insulin-stimulated glycolysis is oxidized, with only a small portion released as lactate or alanine.
This article has been cited by other articles:
|
|
 |
|
  M. G. Clark, M. G. Wallis, E. J. Barrett, M. A. Vincent, S. M. Richards, L. H. Clerk, and S. Rattigan Blood flow and muscle metabolism: a focus on insulin action Am J Physiol Endocrinol Metab, February 1, 2003; 284(2): E241 - E258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. E. Kelley, J. He, E. V. Menshikova, and V. B. Ritov Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes Diabetes, October 1, 2002; 51(10): 2944 - 2950. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. E. KELLEY Skeletal Muscle Triglycerides: An Aspect of Regional Adiposity and Insulin Resistance Ann. N.Y. Acad. Sci., June 1, 2002; 967(1): 135 - 145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Dyck, G. Steinberg, and A. Bonen Insulin increases FA uptake and esterification but reduces lipid utilization in isolated contracting muscle Am J Physiol Endocrinol Metab, September 1, 2001; 281(3): E600 - E607. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. E. Kelley and B. H. Goodpaster Skeletal Muscle Triglyceride: An aspect of regional adiposity and insulin resistance Diabetes Care, May 1, 2001; 24(5): 933 - 941. [Abstract] [Full Text]
|
|
|
|
|
|
A. A. Osman, M. Pendergrass, J. Koval, K. Maezono, K. Cusi, T. Pratipanawatr, and L. J. Mandarino Regulation of MAP kinase pathway activity in vivo in human skeletal muscle Am J Physiol Endocrinol Metab, June 1, 2000; 278(6): E992 - E999. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Kelley, B. Goodpaster, R. R. Wing, and J.-A. Simoneau Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss Am J Physiol Endocrinol Metab, December 1, 1999; 277(6): E1130 - E1141. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-A. SIMONEAU, JACQUES. H. VEERKAMP, L. P. TURCOTTE, and D. E. KELLEY Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss FASEB J, November 1, 1999; 13(14): 2051 - 2060. [Abstract] [Full Text]
|
|
|
|
|
|
J.-A. Simoneau, D. E. Kelley, M. Neverova, and C. H. Warden Overexpression of muscle uncoupling protein 2 content in human obesity associates with reduced skeletal muscle lipid utilization FASEB J, December 1, 1998; 12(15): 1739 - 1745. [Abstract] [Full Text]
|
|
|
|
|
|
M. Pendergrass, E. Fazioni, D. Collins, and R. A. DeFronzo IGF-I increases forearm blood flow without increasing forearm glucose uptake Am J Physiol Endocrinol Metab, August 1, 1998; 275(2): E345 - E350. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Bonadonna, M. P. Saccomani, S. Del Prato, E. Bonora, R. A. DeFronzo, and C. Cobelli Role of Tissue-Specific Blood Flow and Tissue Recruitment in Insulin-Mediated Glucose Uptake of Human Skeletal Muscle Circulation, July 21, 1998; 98(3): 234 - 241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. O'Doherty, A. E. Halseth, D. K. Granner, D. P. Bracy, and D. H. Wasserman Analysis of insulin-stimulated skeletal muscle glucose uptake in conscious rat using isotopic glucose analogs Am J Physiol Endocrinol Metab, February 1, 1998; 274(2): E287 - E296. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Jensen, T. T. Nguyen, A. H. Mijares, C. M. Johnson, and M. J. Murray Effects of gender on resting leg blood flow: implications for measurement of regional substrate oxidation J Appl Physiol, January 1, 1998; 84(1): 141 - 145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Scherrer and C. Sartori Insulin as a Vascular and Sympathoexcitatory Hormone : Implications for Blood Pressure Regulation, Insulin Sensitivity, and Cardiovascular Morbidity Circulation, December 2, 1997; 96(11): 4104 - 4113. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
