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Am J Physiol Endocrinol Metab 258: E1033-E1036, 1990;
0193-1849/90 $5.00
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AJP - Endocrinology and Metabolism, Vol 258, Issue 6 E1033-E1036, Copyright © 1990 by American Physiological Society

ARTICLES

Insulin secretion in Walker 256 tumor cachexia

L. C. Fernandes, U. F. Machado, C. R. Nogueira, A. R. Carpinelli and R. Curi
Department of Physiology and Biophysics, Sao Paulo University, Brazil.

The effect of cachexia on insulin secretion was examined in adult male rats. Isolated islets of Langerhans from Walker 256 tumor-bearing rats secreted less insulin by glucose stimuli as compared with the control group; this was accompanied by significant change in 45Ca2+ outflow rate. Reduced insulin secretion to glucose stimuli in tumor-bearing rats probably led to low insulinemia (one-third). These findings indicate that reduced insulin secretion is probably an important factor for the development of cachexia in Walker 256 tumor-bearing rats.




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