AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 258: E413-E417, 1990;
0193-1849/90 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Iwao, H.
Right arrow Articles by Abe, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Iwao, H.
Right arrow Articles by Abe, Y.

AJP - Endocrinology and Metabolism, Vol 258, Issue 3 E413-E417, Copyright © 1990 by American Physiological Society

ARTICLES

Elevated angiotensinogen mRNA levels in rat liver by nephrectomy

H. Iwao, S. Kimura, K. Fukui, A. Nakamura, T. Tamaki, H. Ohkubo, S. Nakanishi and Y. Abe
Department of Pharmacology, Kagawa Medical School, Japan.

The expression of the angiotensinogen gene was studied in nephrectomized rats with and without adrenal glands. Angiotensinogen mRNA was measured by a sensitive radiodensitometric hybridization assay. Angiotensinogen mRNA levels in the liver increased 5 times by nephrectomy alone and 2.6 times by nephrectomy with adrenalectomy in acute experiments. Brain mRNA levels remained the same in both groups. When nephrectomy was performed 7 days after adrenalectomy, mRNA level increased by 50%. Angiotensinogen mRNA increased 5 times in the liver and 2.3 times in the brain by the administration of dexamethasone. An additive effect on liver angiotensinogen mRNA level was observed in nephrectomy with dexamethasone treatment. These results suggest that in nephrectomy, a synergetic action of glucocorticoids and other unknown factors increase hepatic angiotensinogen mRNA levels.


This article has been cited by other articles:


Home page
 HypertensionHome page
N. Nyui, K. Tamura, S. Yamaguchi, M. Nakamaru, T. Ishigami, M. Yabana, M. Kihara, H. Ochiai, N. Miyazaki, S. Umemura, et al.
Tissue Angiotensinogen Gene Expression Induced by Lipopolysaccharide in Hypertensive Rats
Hypertension, October 1, 1997; 30(4): 859 - 867.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online