AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 258: E399-E412, 1990;
0193-1849/90 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Simonson, D. C.
Right arrow Articles by DeFronzo, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Simonson, D. C.
Right arrow Articles by DeFronzo, R. A.

AJP - Endocrinology and Metabolism, Vol 258, Issue 3 E399-E412, Copyright © 1990 by American Physiological Society

ARTICLES

Indirect calorimetry: methodological and interpretative problems

D. C. Simonson and R. A. DeFronzo
Department of Internal Medicine, Joslin Diabetes Center, New England Deaconess Hospital, Boston, Massachusetts.

The technique of indirect calorimetry is now widely used to examine rates of energy production and substrate oxidation in humans. Although the basic principles of indirect calorimetry are well established, it is important to recognize that there are several potential pitfalls in the methodology and data interpretation that must be appreciated to properly understand and apply the results derived from this technique. In particular, one must recognize that the fundamental measurement provided by indirect calorimetry is the net disappearance rate of a substrate regardless of the metabolic interconversions that the substrate may undergo before its disappearance from its metabolic pool. Under most circumstances, direct oxidation represents the major route by which a substrate disappears from its metabolic pool, and the two terms are often used interchangeably. However, under conditions when rates of gluconeogenesis, ketogenesis, or lipogenesis are elevated, the presumed equivalence between oxidation and disappearance may no longer apply, even though the actual measurements derived from indirect calorimetry remain valid. When indirect calorimetry is combined with other in vivo metabolic techniques (e.g., the insulin clamp or radioisotope turnover methods) it can provide a powerful tool for noninvasively examining complex metabolic processes.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
B. C. Bergman, M.-A. Cornier, T. J. Horton, and D. H. Bessesen
Effects of fasting on insulin action and glucose kinetics in lean and obese men and women
Am J Physiol Endocrinol Metab, October 1, 2007; 293(4): E1103 - E1111.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. F. Zwemer, M. Y. Song, K. A. Carello, and L. G. D'Alecy
Strain differences in response to acute hypoxia: CD-1 versus C57BL/6J mice
J Appl Physiol, January 1, 2007; 102(1): 286 - 293.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
P. Kok, F. Roelfsema, M. Frolich, J. van Pelt, M. P. M. Stokkel, A. E. Meinders, and H. Pijl
Activation of dopamine D2 receptors simultaneously ameliorates various metabolic features of obese women
Am J Physiol Endocrinol Metab, November 1, 2006; 291(5): E1038 - E1043.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. J. Horton, E. K. Miller, and K. Bourret
No effect of menstrual cycle phase on glycerol or palmitate kinetics during 90 min of moderate exercise
J Appl Physiol, March 1, 2006; 100(3): 917 - 925.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. A. Evans, A. D. Parsons, and J. M. Overton
Homeostatic responses to caloric restriction: influence of background metabolic rate
J Appl Physiol, October 1, 2005; 99(4): 1336 - 1342.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. A. Evans, M. M. Messina, W. D. Knight, A. D. Parsons, and J. M. Overton
Long-Evans and Sprague-Dawley rats exhibit divergent responses to refeeding after caloric restriction
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1468 - R1476.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
S. R. Kashyap, R. Belfort, R. Berria, S. Suraamornkul, T. Pratipranawatr, J. Finlayson, A. Barrentine, M. Bajaj, L. Mandarino, R. DeFronzo, et al.
Discordant effects of a chronic physiological increase in plasma FFA on insulin signaling in healthy subjects with or without a family history of type 2 diabetes
Am J Physiol Endocrinol Metab, September 1, 2004; 287(3): E537 - E546.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. S. MacLean, J. A. Higgins, G. C. Johnson, B. K. Fleming-Elder, J. C. Peters, and J. O. Hill
Metabolic adjustments with the development, treatment, and recurrence of obesity in obesity-prone rats
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2004; 287(2): R288 - R297.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. R. Mazan, E. F. Deveney, S. DeWitt, D. Bedenice, and A. Hoffman
Energetic cost of breathing, body composition, and pulmonary function in horses with recurrent airway obstruction
J Appl Physiol, July 1, 2004; 97(1): 91 - 97.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
M. M Buijs, J. Burggraaf, C. Wijbrandts, M. L de Kam, M. Frolich, A. F Cohen, J. A Romijn, H. P Sauerwein, A E. Meinders, and H. Pijl
Blunted lipolytic response to fasting in abdominally obese women: evidence for involvement of hyposomatotropism
Am. J. Clinical Nutrition, March 1, 2003; 77(3): 544 - 550.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
N. Landry, N. Bergeron, R. Archer, P. Samson, L. Corneau, J. Bergeron, and O. Deriaz
Whole-body fat oxidation rate and plasma triacylglycerol concentrations in men consuming an ad libitum high-carbohydrate or low-carbohydrate diet
Am. J. Clinical Nutrition, March 1, 2003; 77(3): 580 - 586.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J.A. Paniagua, J. Lopez-Miranda, A. Escribano, F.J. Berral, C. Marin, D. Bravo, E. Paz-Rojas, P. Gomez, M. Barcos, J.A. Moreno, et al.
Cerivastatin Improves Insulin Sensitivity and Insulin Secretion in Early-State Obese Type 2 Diabetes
Diabetes, August 1, 2002; 51(8): 2596 - 2603.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
U. Holmback, A. Forslund, J. Forslund, L. Hambraeus, M. Lennernas, A. Lowden, M. Stridsberg, and T. Akerstedt
Metabolic Responses to Nocturnal Eating in Men Are Affected by Sources of Dietary Energy
J. Nutr., July 1, 2002; 132(7): 1892 - 1899.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
T. Pratipanawatr, W. Pratipanawatr, C. Rosen, R. Berria, M. Bajaj, K. Cusi, L. Mandarino, S. Kashyap, R. Belfort, and R. A. DeFronzo
Effect of IGF-I on FFA and glucose metabolism in control and type 2 diabetic subjects
Am J Physiol Endocrinol Metab, June 1, 2002; 282(6): E1360 - E1368.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
T. Pratipanawatr, K. Cusi, P. Ngo, W. Pratipanawatr, L. J. Mandarino, and R. A. DeFronzo
Normalization of Plasma Glucose Concentration by Insulin Therapy Improves Insulin-Stimulated Glycogen Synthesis in Type 2 Diabetes
Diabetes, February 1, 2002; 51(2): 462 - 468.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
J. C Desport, P. M Preux, L. Magy, Y. Boirie, J. M Vallat, and B. Beaufrere
Factors correlated with hypermetabolism in patients with amyotrophic lateral sclerosis
Am. J. Clinical Nutrition, September 1, 2001; 74(3): 328 - 334.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. R. Tagliaferro and A. M. Ronan
Physiological levels and action of dehydroepiandrosterone in Yucatan miniature swine
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2001; 281(1): R1 - R9.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. J. Toth, C. K. Sites, W. T. Cefalu, D. E. Matthews, and E. T. Poehlman
Determinants of insulin-stimulated glucose disposal in middle-aged, premenopausal women
Am J Physiol Endocrinol Metab, July 1, 2001; 281(1): E113 - E121.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
W. Demark-Wahnefried, B. L. Peterson, E. P. Winer, L. Marks, N. Aziz, P. K. Marcom, K. Blackwell, and B. K. Rimer
Changes in Weight, Body Composition, and Factors Influencing Energy Balance Among Premenopausal Breast Cancer Patients Receiving Adjuvant Chemotherapy
J. Clin. Oncol., May 1, 2001; 19(9): 2381 - 2389.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
P. Iozzo, T. Pratipanawatr, H. Pijl, C. Vogt, V. Kumar, R. Pipek, M. Matsuda, L. J. Mandarino, K. J. Cusi, and R. A. DeFronzo
Physiological hyperinsulinemia impairs insulin-stimulated glycogen synthase activity and glycogen synthesis
Am J Physiol Endocrinol Metab, May 1, 2001; 280(5): E712 - E719.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. J. Horton and J. O. Hill
Prolonged fasting significantly changes nutrient oxidation and glucose tolerance after a normal mixed meal
J Appl Physiol, January 1, 2001; 90(1): 155 - 163.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
R. G. Hankard, M. W. Haymond, and D. Darmaun
Role of glucose in the regulation of glutamine metabolism in health and in type 1 insulin-dependent diabetes
Am J Physiol Endocrinol Metab, September 1, 2000; 279(3): E608 - E613.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
P. CASTELLINO, L. LUZI, M. GIORDANO, and R. A. DEFRONZO
Effects of Insulin and Amino Acids on Glucose and Leucine Metabolism in CAPD Patients
J. Am. Soc. Nephrol., May 1, 1999; 10(5): 1050 - 1058.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
T. J. Horton, M. J. Pagliassotti, K. Hobbs, and J. O. Hill
Fuel metabolism in men and women during and after long-duration exercise
J Appl Physiol, November 1, 1998; 85(5): 1823 - 1832.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
S. Fazio, D. Sabatini, B. Capaldo, C. Vigorito, A. Giordano, R. Guida, F. Pardo, B. Biondi, and L. Sacca
A Preliminary Study of Growth Hormone in the Treatment of Dilated Cardiomyopathy
N. Engl. J. Med., March 28, 1996; 334(13): 809 - 814.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
T. J. Horton, E. K. Miller, D. Glueck, and K. Tench
No effect of menstrual cycle phase on glucose kinetics and fuel oxidation during moderate-intensity exercise
Am J Physiol Endocrinol Metab, April 1, 2002; 282(4): E752 - E762.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online