| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Endocrinology and Metabolism, Vol 258, Issue 2 E382-E389, Copyright © 1990 by American Physiological Society
ARTICLES |
R. R. Wolfe, S. Klein, F. Carraro and J. M. Weber
Metabolism Research Unit, Shriners Burns Institute, Galveston, Texas.
We have investigated the role of triglyceride-fatty acid cycling in amplifying control of the net flux of fatty acids in response to exercise and in recovery from exercise. Five normal volunteers were infused with [1-13C]palmitate and D-5-glycerol throughout rest, 4 h of treadmill exercise at 40% maximum O2 consumption, and 2 h of recovery. Total fat oxidation was quantified by indirect calorimetry. Lipolysis (rate of appearance of glycerol) increased from 2.1 +/- 0.3 to 6.0 +/- 1.2 mumol.kg-1.min-1 after 30 min of exercise and progressively increased thereafter to a value of 10.5 +/- 0.8 mumol.kg-1.min-1 after 4 h. Lipolysis decreased rapidly during the first 20 min of recovery, but it was still significantly elevated after 2 h of recovery. The rate of appearance of free fatty acids followed the same pattern of response. Seventy percent of released fatty acids were reesterified at rest, and this value decreased to 25% within the first 30 min of exercise. Reesterification remained less than 35% of lipolysis until the start of recovery, at which time the value rose to 90%. In exercise, more than one-half the increase in fat oxidation could be attributed to the reduction in the percent reesterification. Most of the change in percent reesterification during exercise and recovery was caused by changes in extracellular cycling of fatty acids released into plasma. We conclude that triglyceride-fatty acid cycling plays an important role in enabling a rapid response of fatty acid metabolism to major changes in energy metabolism.
This article has been cited by other articles:
|
|
 |
|
  L. Magnoni, E. Vaillancourt, and J.-M. Weber High resting triacylglycerol turnover of rainbow trout exceeds the energy requirements of endurance swimming Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2008; 295(1): R309 - R315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. C. Henderson, J. A. Fattor, M. A. Horning, N. Faghihnia, M. L. Johnson, T. L. Mau, M. Luke-Zeitoun, and G. A. Brooks Lipolysis and fatty acid metabolism in men and women during the postexercise recovery period J. Physiol., November 1, 2007; 584(3): 963 - 981. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Raney and L. P. Turcotte Regulation of contraction-induced FA uptake and oxidation by AMPK and ERK1/2 is intensity dependent in rodent muscle Am J Physiol Endocrinol Metab, December 1, 2006; 291(6): E1220 - E1227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Salinari, A. Bertuzzi, A. Gandolfi, A. V. Greco, A. Scarfone, M. Manco, and G. Mingrone Dodecanedioic acid overcomes metabolic inflexibility in type 2 diabetic subjects Am J Physiol Endocrinol Metab, November 1, 2006; 291(5): E1051 - E1058. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Watt, A. G. Holmes, S. K. Pinnamaneni, A. P. Garnham, G. R. Steinberg, B. E. Kemp, and M. A. Febbraio Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue Am J Physiol Endocrinol Metab, March 1, 2006; 290(3): E500 - E508. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Jacobs, G. A. Casazza, S.-H. Suh, M. A. Horning, and G. A. Brooks Fatty acid reesterification but not oxidation is increased by oral contraceptive use in women J Appl Physiol, May 1, 2005; 98(5): 1720 - 1731. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Kalderon, N. Mayorek, L. Ben-Yaacov, and J. Bar-Tana Adipose tissue sensitization to insulin induced by troglitazone and MEDICA 16 in obese Zucker rats in vivo Am J Physiol Endocrinol Metab, April 1, 2003; 284(4): E795 - E803. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. F. Bernard, C. Fayolle, J.-P. Robin, and R. Groscolas Glycerol and NEFA kinetics in long-term fasting king penguins: phase II versus phase III J. Exp. Biol., September 1, 2002; 205(17): 2745 - 2754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yamazaki, M. Arai, S. Matsumura, K. Inoue, and T. Fushiki Intracranial administration of transforming growth factor-beta 3 increases fat oxidation in rats Am J Physiol Endocrinol Metab, September 1, 2002; 283(3): E536 - E544. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Park, V. K. Kaushik, S. Constant, M. Prentki, E. Przybytkowski, N. B. Ruderman, and A. K. Saha Coordinate Regulation of Malonyl-CoA Decarboxylase, sn-Glycerol-3-phosphate Acyltransferase, and Acetyl-CoA Carboxylase by AMP-activated Protein Kinase in Rat Tissues in Response to Exercise J. Biol. Chem., August 30, 2002; 277(36): 32571 - 32577. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. F. Bernard, E. Mioskowski, and R. Groscolas Blockade of fatty acid oxidation mimics phase II-phase III transition in a fasting bird, the king penguin Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2002; 283(1): R144 - R152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. C. Van Aggel-Leijssen, W. H. M. Saris, A. J. M. Wagenmakers, J. M. Senden, and M. A. Van Baak Effect of exercise training at different intensities on fat metabolism of obese men J Appl Physiol, March 1, 2002; 92(3): 1300 - 1309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Melanson, T. A. Sharp, H. M. Seagle, T. J. Horton, W. T. Donahoo, G. K. Grunwald, J. T. Hamilton, and J. O. Hill Effect of exercise intensity on 24-h energy expenditure and nutrient oxidation J Appl Physiol, March 1, 2002; 92(3): 1045 - 1052. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Reidy and J.-M. Weber Accelerated substrate cycling: a new energy-wasting role for leptin in vivo Am J Physiol Endocrinol Metab, February 1, 2002; 282(2): E312 - E317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. B. McClelland, P. W. Hochachka, S. P. Reidy, and J.-M. Weber High-altitude acclimation increases the triacylglycerol/fatty acid cycle at rest and during exercise Am J Physiol Endocrinol Metab, September 1, 2001; 281(3): E537 - E544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. A. Lynch, B. J. Nicklas, D. M. Berman, K. E. Dennis, and A. P. Goldberg Reductions in visceral fat during weight loss and walking are associated with improvements in {V}O2 max J Appl Physiol, January 1, 2001; 90(1): 99 - 104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Pritzlaff, L. Wideman, J. Blumer, M. Jensen, R. D. Abbott, G. A. Gaesser, J. D. Veldhuis, and A. Weltman Catecholamine release, growth hormone secretion, and energy expenditure during exercise vs. recovery in men J Appl Physiol, September 1, 2000; 89(3): 937 - 946. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. F Coyle Physical activity as a metabolic stressor Am. J. Clinical Nutrition, August 1, 2000; 72(2): 512S - 520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F Horowitz and S. Klein Lipid metabolism during endurance exercise Am. J. Clinical Nutrition, August 1, 2000; 72(2): 558S - 563. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Kalderon, N. Mayorek, E. Berry, N. Zevit, and J. Bar-Tana Fatty acid cycling in the fasting rat Am J Physiol Endocrinol Metab, July 1, 2000; 279(1): E221 - E227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. B. McClelland, P. W. Hochachka, and J.-M. Weber Effect of high-altitude acclimation on NEFA turnover and lipid utilization during exercise in rats Am J Physiol Endocrinol Metab, December 1, 1999; 277(6): E1095 - E1102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Friedlander, G. A. Casazza, M. A. Horning, A. Usaj, and G. A. Brooks Endurance training increases fatty acid turnover, but not fat oxidation, in young men J Appl Physiol, June 1, 1999; 86(6): 2097 - 2105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Horowitz, R. Mora-Rodriguez, L. O. Byerley, and E. F. Coyle Substrate metabolism when subjects are fed carbohydrate during exercise Am J Physiol Endocrinol Metab, May 1, 1999; 276(5): E828 - E835. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Jensen Regional glycerol and free fatty acid metabolism before and after meal ingestion Am J Physiol Endocrinol Metab, May 1, 1999; 276(5): E863 - E869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Forslund, A. E. El-Khoury, R. M. Olsson, A. M. Sjodin, L. Hambraeus, and V. R. Young Effect of protein intake and physical activity on 24-h pattern and rate of macronutrient utilization Am J Physiol Endocrinol Metab, May 1, 1999; 276(5): E964 - E976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. W. Coppack, M. Persson, R. L. Judd, and J. M. Miles Glycerol and nonesterified fatty acid metabolism in human muscle and adipose tissue in vivo Am J Physiol Endocrinol Metab, February 1, 1999; 276(2): E233 - E240. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. B. Rasmussen, C. R. Hancock, and W. W. Winder Postexercise recovery of skeletal muscle malonyl-CoA, acetyl-CoA carboxylase, and AMP-activated protein kinase J Appl Physiol, November 1, 1998; 85(5): 1629 - 1634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Friedlander, G. A. Casazza, M. A. Horning, T. F. Buddinger, and G. A. Brooks Effects of exercise intensity and training on lipid metabolism in young women Am J Physiol Endocrinol Metab, November 1, 1998; 275(5): E853 - E863. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Robinson, W. V. Tamborlane, D. G. Maggs, S. Enoksson, R. S. Sherwin, D. Silver, G. I. Shulman, and S. Caprio Effect of insulin on glycerol production in obese adolescents Am J Physiol Endocrinol Metab, April 1, 1998; 274(4): E737 - E743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ranneries, J. Bulow, B. Buemann, N. J. Christensen, J. Madsen, and A. Astrup Fat metabolism in formerly obese women Am J Physiol Endocrinol Metab, January 1, 1998; 274(1): E155 - E161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. B. Rasmussen and W. W. Winder Effect of exercise intensity on skeletal muscle malonyl-CoA and acetyl-CoA carboxylase J Appl Physiol, October 1, 1997; 83(4): 1104 - 1109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Horowitz, R. Mora-Rodriguez, L. O. Byerley, and E. F. Coyle Lipolytic suppression following carbohydrate ingestion limits fat oxidation during exercise Am J Physiol Endocrinol Metab, October 1, 1997; 273(4): E768 - E775. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Short and D. A. Sedlock Excess postexercise oxygen consumption and recovery rate in trained and untrained subjects J Appl Physiol, July 1, 1997; 83(1): 153 - 159. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
