AJP - Endocrinology and Metabolism, Vol 256, Issue 6 E740-E746, Copyright © 1989 by American Physiological Society
HDL subfractions and adipose tissue metabolism in the reduced-obese state
R. H. Eckel and T. J. Yost
Department of Medicine, University of Colorado Health Sciences Center, Denver 80262.
The effect of weight reduction on fasting serum lipids and lipoproteins and
adipose tissue lipoprotein lipase responsiveness to insulin was assessed
immediately after and 3 mo subsequent to a mean 11.7% weight reduction in
14 women. Whereas reduction in fasting serum triglycerides persisted after
3 mo, reductions in serum cholesterol, low-density lipoprotein cholesterol
and high-density lipoprotein (HDL) cholesterol were not found at 3 mo. In
fact, at 3 mo, levels of HDL cholesterol were higher than before weight
reduction. Maintenance of the reduced-obese state also increased the
HDL2-to-HDL3 cholesterol ratio (P less than 0.01), an effect strongly
associated with the change in the responsiveness of adipose tissue
lipoprotein lipase to insulin (r = 0.821, P less than 0.001). Moreover,
after maintenance of the reduced-obese state, the HDL2-to-HDL3 cholesterol
ratio also increased after the ingestion of corn oil and a 6-h
insulin-glucose infusion, a response not present before weight reduction.
Thus the effect of weight reduction on serum lipids and lipoproteins was
not only time dependent, but for HDL, was strongly associated with changes
in adipose tissue metabolism.
