AJP - Endocrinology and Metabolism, Vol 255, Issue 6 E850-E856, Copyright © 1988 by American Physiological Society

ARTICLES

Adrenalectomy eliminates both fiber-type differences and starvation effects on denervated muscle

R. R. Almon and D. C. Dubois
Department of Biological Sciences, State University of New York, Buffalo 14260.

This report describes changes in muscle mass of innervated and denervated pairs of muscles taken from intact and adrenalectomized 250-g male Sprague-Dawley rats provided with different diets. Diets ranged from a nutritionally complete liquid diet to starvation (water only). In the intact animals, muscles with a more tonic character (soleus) are less sensitive to starvation than are muscles with a more phasic character (extensor digitorum longus), whereas the opposite is true of denervation. In the intact animals, starvation greatly increased the amount of atrophy following denervation. In the adrenalectomized animals, starvation had no effect on the amounts of atrophy following denervation. Furthermore, adrenalectomy virtually eliminated the fiber-type differences in the amount of atrophy following denervation. In addition, a comparison between denervated muscles from intact animals and adrenalectomized animals subjected to starvation demonstrates that all denervated muscles from the adrenalectomized animals atrophy less. Finally, it was observed that although an adrenalectomized animal can tolerate 6 days of starvation, an adrenalectomized-castrated animal cannot tolerate even short periods of starvation. The difference appears to be due to low amounts of corticosterone of testicular origin.

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				R. R. Almon, D. C. DuBois, Z. Yao, E. P. Hoffman, S. Ghimbovschi, and W. J. Jusko Microarray analysis of the temporal response of skeletal muscle to methylprednisolone: comparative analysis of two dosing regimens Physiol Genomics, August 20, 2007; 30(3): 282 - 299. [Abstract] [Full Text] [PDF]