AJP - Endocrinology and Metabolism, Vol 255, Issue 4 E449-E455, Copyright © 1988 by American Physiological Society
Effect of vasopressin on atrial natriuretic peptide release and renal function in dogs
M. Inoue, T. Kimura, K. Ota, K. Iitake, M. Shoji, K. Sato, M. Ota and K. Yoshinaga
Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
To assess the effect of arginine vasopressin (AVP) and 1-deamino-8-D-AVP
(DDAVP) on atrial natriuretic peptide (ANP) release, renal water and
electrolyte excretion, and cardiovascular function, AVP and DDAVP were
administered at a dose of 10 ng.kg-1.min-1 iv for 30 min into anesthetized
dogs receiving saline infusion at a rate of 1 ml.kg-1.min-1 (n = 12). In
the control study, saline was infused alone (n = 6). AVP potentiated the
plasma ANP response to an increase in plasma volume produced by saline
infusion, increased mean arterial blood pressure (MAP), and exaggerated the
natriuresis and kaliuresis. DDAVP did not potentiate the increase in plasma
ANP but enhanced the natriuresis without any rise in MAP. Saline alone
increased plasma ANP as well as sodium and potassium excretion with no
changes in MAP. Inulin and p-aminohippuric acid clearances did not change
during these studies. The results suggest that in hydrated dogs, AVP may
increase ANP release and arterial blood pressure via the vasopressor
activity of AVP and potentiate the natriuresis and kaliuresis, but the
increased ANP may play little role in the natriuresis.
